Research groups > Biochemistry of cancer > Lines of research
Go to content (click on Intro)
UdG Home UdG Home
UdG 30 years

Research Group in Biochemistry of Cancer

Lines of research

Cancer therapy and diagnosis

Main lines of research

The group's research focuses on the field of cancer therapy and diagnosis. Two lines of research are worked on in particular:

1. Glycobiology and cancer:

Finding molecular markers that enable cancer to be diagnosed in its early stages, where current therapies are most effective, and which can also be used for improving tumour prognoses and follow-ups, and in the study of glycoenzymes involved in adhesion and metastasis processes, for possible treatment against their effects. Research. Heads: Dr Rosa Peracaula and Dr Esther Llop.

1.1. Tumour markers: anomalous glycosilation of various seric proteins as possible carcinoma tumour markers.

Presently focused on pancreatic and prostate carcinomas, in particular the anomalous glycosilation of over-expressed or new-expressed seric glycoproteins in pancreatic cancer and of PSAs (prostate-specific antigens). Extensible to other glycoproteins (Proteomics and Glycomics).

Molecular mechanisms responsible for changes in glycosylation in tumours

Studies of the expression of glycosyl transferases responsible for the biosynthesis of carbohydrate antigens associated with tumour, determination of their implication in different stages of tumour progression and of the factors that regulate its expression.

2. Targeted anti-tumour therapies (TAD): 

Development of molecules with anti-tumour activity, that go against specific targets in cancerous cells. Research. Head: Dr Anna Massaguer

2.1 epidermal growth factor (EGF) analogues as anti-tumour agents

Design and production of derivatives of family EGF growth factors (Truncated EGF and other modified ligands) with potential anti-tumour activity. Study of the resistance mechanisms to targeted therapies against EGF receptors, through the appearance of autocrine loops from the EGF/ErbB pathway. 

2.2 Vehiculation of anti-tumour compounds-

Characterisation of transition-metal based complexes as potential anti-tumour agents. Study of their activity in photochemotherapy. Design and production of vehicular peptides for targeting chemotherapeutic agents to over-expressed receptors in tumours (EGF derivatives and bombesin, octreotide and RGD-peptide derivatives etc.)

Choose which types of cookies you accept which the University of Girona can store in your browser.

Those that are essential for enabling your connection. There is no option for disabling them, as they are necessary for the functioning of the website.

These enable your options to be remembered (for example language or region you are accessing from), to provide you with advanced services.

They provide statistical information and enable improved services. We use Google Analytics cookies which you can deactivate by installing this plugin.

To offer advertising contents relating to the interests of users, either directly, or through third parties (“adservers”). These must be activated if you wish to see the YouTube videos uploaded to the University of Girona’s website.