Estudia

• CB01- Identificar problemes, buscar solucions originals i aplicar-les en un context d'investigació o professional
• CB04- Comunicar de forma clara i concisa els seus coneixements, les seves conclusions i les implicacions ètiques i socials del seu camp de treball a públics especialitzats i no especialitzats ( divulgació científica)
• CB05- Actualitzar i prosseguir els seus estudis de forma auto-dirigida i autònoma, recollint i seleccionant la informació necessària que permeti una investigació original i que aporti nous coneixements
• CE01- Integrar els aspectes metodològics i els continguts de les diferents disciplines de les biociències per al seu estudi a nivell molecular
• CE04- Identificar i analitzar els mecanismes moleculars bàsics que operen en els éssers vius, particularment l'home, així com les seves aplicacions en diferents camps d'investigació
• CE05- Gestionar i planificar l'ús racional de tècniques freqüents en Biología Molecular en noves situacions d'estudi o experimentació
• CE06- Avaluar l'ús i la necessitat de tècniques avançades en biología molecular així com la seva adaptació a necessitats particulars requerides
• CE08- Valorar la utilitat de tècniques de modificació genètica d'organismes per a estudis i tractament de patologies humanes, la millora de processos i productes biotecnològics
• CE09- Identificar i utilitzar racionalment les eines bio-informàtiques bàsiques ( bases de dades i programes d'anàlisis molecular) per contribuir al coneixement genòmic, transcriptòmic i proteòmic
• CE10- Identificar i generar solucions a problemes plantejats en els àmbits de la Biomediciona Molecular i la Patologia Molecular

1. Protein engineering as a way to develop biological therapeutics. Different examples of Knowledge-based mutagenesis (KBM) and directed evolution (DE) to develop or control the activity of protein drugs.

2. Screening methodologies of mutant libraries.

3. Modular drugs. Are the “magic bullets" possible? General survey and examples. Modular drugs and directed evolution as a way to control protein drug activity.

4. Examples of smart response drug system design. Targeted drug neutralization. Targeted drug activation. Engineered Zymogens (EZ), Directed Enzyme Prodrug therapy (DEPT).

• Smales, C. Mark James, David C. (cop. 2005 ). Therapeutic proteins : methods and protocols . New Jersey: Humana Press. Catàleg
• Kannicht, Christoph (cop. 2002 ). Posttranslational modifications of proteins : tools for functional proteomics . Totowa, N.J.: Humana Press. Catàleg
• Dieken, Markus Leyck (2002 ). Insulin & related proteins. Dordrecht [etc.]: Kluwer Academic Publishers. Recuperat 12-07-2010, a http://ebooks.springerlink.com/UrlApi.aspx?action=summary&v=1&bookid=78489 Catàleg
• Fruton, Joseph S (cop. 1999 ). Proteins, enzymes, genes : the interplay of chemistry andbiology . New Haven, CT [etc.]: Yale University Press. Catàleg
• Creighton, Thomas E (1993 ). Proteins : structures and molecular properties (2nd ed.). New York: Freeman. Catàleg
• Lesk, Arthur M (cop. 2001 ). Introduction to protein architecture : the structural biology of proteins . Oxford, UK: Oxford University Press. Catàleg
• Watson, James D. (cop. 2007 ). Recombinant DNA : genes and genomes, a short course (3th ed.). New York: W. H. Freema and Co. Catàleg
• Glick, Bernard R (cop. 2003 ). Molecular biotechnology : principles and applications of recombinant DNA (3rd ed.). Washington: ASM Press. Catàleg
• Robertson, Dominique (cop. 1997 ). Manipulation and expression of recombinant DNA : a laboratory manual . San Diego [etc.]: Academic Press. Catàleg
• Eun, Hyone-Myong (cop. 1996 ). Enzymology primer for recombinant DNA technology . San Diego (Calif.) [etc.]: Academic Press. Catàleg
• Emery, Alan E. H (cop. 1995 ). An Introduction to recombinant DNA in medicine (2nd ed). Chichester [etc.]: Wiley. Catàleg
• Watson, James D. (1992 ). Recombinant DNA (2nd ed.). New York: Scientific American Books. Catàleg
• Glover, David M. Hames, B. D. (1995 ). DNA cloning : a practical approach (2nd ed.). Oxford [etc.]: IRL Press. Catàleg

Activitats d'avaluació:

Written reports and oral presentations will be individual whenever possible. If it is necessary to work in teams the final mark of the written report will be the same for all the team members unless negligence is detected.

In the oral presentation it is obligatory to specify which part of the work has been done by each team member independently of the organization of the exposition.

REMARCK: If fraudulent activity is detected in any of the exercises required for the evaluation of a subject, it will result in failure to pass it, regardless of the disciplinary process that may be followed against the offending student.
Fraudulent activity includes but it is not restricted to: use of information without authorization, use of false information, use of unauthorized devices, impersonation, total or partial plagiarism, purchase and sale of tests, practices and assignments, etc.

Uses of AI programs:
It is not allowed the use of AI tools to generate text, like ChatGPT, to elaborate the oral presentation or the written work.
If you use other AI tools, for instance to search information, generate figures…etc, it has to be clearly stated both in the oral presentation and in the written work.

Criteris específics de la nota «No Presentat»:
The qualification will be NOT PRESENTED if the written report is not presented and/or the oral presentation is not given. It is mandatory the assistance to a minimum of the 80% of the sessions including the presentation of the works carried out by the rest of classmates.

Avaluació única:
Students can opt for a single evaluation that would consist in a written work about a scientic subject related to the content of the course. This work will account for the 100% of the final grade obtained by the student and if failedit may be presented again only once.

Students should attend a minimum of 60% of the lectures to get the option for this single evaluation.

Requisits mínims per aprovar:
To pass the course student have to achieve a mark or 5 or higher over 10

Students (single or in reduced groups) can contact teacher by mail and agree a tutorial meeting to solve doubts about the content of the course.

General notifications to the students will be done through the Moodle Platform.

The main way of teachers-students communication will be by mail. Students and teacher can agree an appointment for a meeting (single or in reduced group) at a time and place suitable for both to solve any kind of doubts that cannot be solved by mail.

Scientific articles used in the lecture sessions to illustrate the different startegies to generate protein drugs are uploaded on the web page of the course.