1. Chronobiology – biological rhythms, the circadian rhythm, entrainment of the biological clock, light and other zeitgebers, circadian rhythms and metabolism
2. Anatomy and physiology of the circadian system – the suprachiasmatic nucleus, central and peripheral circadian oscillators, the pineal gland, regulation of melatonin secretion, functions of melatonin
3. Clock and clock-controlled genes – daily rhythmic expression, transcription-translation feedback loops (TTFLs), generation and regulation of circadian rhythms
4. Chronotype – types of chronotype, actigraphy and measure of circadian rhythms
5. Sleep Physiology – sleep disorders due to alterations of the circadian rhythm, Light at Night, circadian clock misalignment, shift work and jet lag
6. Chronodisruption – circadian rhythm misalignment, predisposition to pathologies
7. Chronotherapy – circadian realignment, circadian regulation of drug pharmacodynamics and pharmacokinetics
- Evaluation of PBL sessions will be worth 50 % of the total subject grade, proportionally according to the following approved criteria:
. Learning Abilities (25%)
. Communication (25%)
. Responsibility (25%)
. Interpersonal Relationships (25%)
- Evaluation of the PBL exam will be worth the remaining 50 %, as follows:
. Part 1 (50%)
- Clear understanding of the topic and proper usage of knowledge from the learning objectives of the module to provide a potential explanation for the situation; evaluation guidelines will vary for each exam (90%)
- Organization of the text, clear style and language (10%)
. Part 2 (50%)
- Adequate, specific and unambiguous answer to the questions on the exam (90%)
- Organization of the text, clear style and language (10%)
Criteris específics de la nota «No Presentat»:
- Minimum Requirement:
. Students must submit at least 80% by weight of the assessed components.
. PBL sessions cannot be retaken; qualification in these must be at least 50/100.