Laura Miró, Júlia López, Pedro E Guerrero, Neus Martínez-Bosch, Noemí Manero-Rupérez, Mireia Moreno, M Rosa Ortiz, Esther Llop, Pilar Navarro, Rosa Peracaula. "Sialyltransferase Inhibitor Ac53FaxNeu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice." Cancers 14 (2022): 6133-. Adrià Duran; Pedro Enrique Guerrero; Maria Rosa Ortiz; Dúnia Pérez del Campo; Ernesto Castro; Adelaida Garcia-Velasco; Esther Fort; Rafael de Llorens; Radka Saldova; Esther Llop; Rosa Peracaula "Characterization of mesothelin glycosylation in pancreatic cancer: decreased core fucosylated glycoforms in pancreatic cancer patients' sera." Biomedicines 10 (2022): 1942-. Greville G; Llop E; Howard J; Madden SF; Perry AS; Peracaula R; Rudd PM; McCann A; Saldova R. "5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells." Clinical Epigenetics 13 (2021): -. Pedro Enrique Guerrero; Adrià Duran; Maria Rosa Ortiz; Ernesto Castro; Adelaida Garcia-Velasco; Esther Llop; Rosa Peracaula "Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl-Lewis x (sLex) in pancreatic adenocarcinoma." Journal of Proteomics 231 (2021): 104004-. Anna Gratacós-Mulleras, Adrià Duran, Akram Asadi Shehni, Montserrat Ferrer-Batallé, Manel Ramírez, Josep Comet, Rafael de Llorens, Radka Saldova, Esther Llop, Rosa Peracaula "Characterisation of the main PSA glycoforms in aggressive prostate cancer." Scientific Reports 10 (2020): -. Pedro Enrique Guerrero , Laura Miró, Bin S Wong,, Anna Massaguer, Neus Martínez-Bosch, Rafael de Llorens, Pilar Navarro, Konstantinos Konstantopoulos, Esther Llop, Rosa Peracaula "Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion." International Journal of Molecular Sciences (2020): -. Greville G, Llop E, Huang C, Creagh-Flynn J, Pfister S, O'Flaherty R, Madden SF, Peracaula R, Rudd PM, McCann A, Saldova R "Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro." Frontiers in Oncology (2020): -. Mancera-Arteu, M., Giménez, E., Balmaña, M., Barrabés, S., Albiol-Quer, M., Fort, E., Peracaula, R., Sanz-Nebot, V. "Multivariate data analysis for the detection of human alpha-acid glycoprotein aberrant glycosylation in pancreatic ductal adenocarcinoma.." Journal of Proteomics 195 (2019): 76-87. Llop E, E Guerrero P, Duran A, Barrabés S, Massaguer A, José Ferri M, Albiol-Quer M, de Llorens R, Peracaula R. "Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma." World Journal of Gastroenterology 24 (2018): 2537-2554. Meritxell Balmaña; Adrià Duran; Catarina Gomes; Esther Llop; Raquel López-Martos; M.Rosa Ortiz; Sílvia Barrabés; Celso A. Reis; Rosa Peracaula "Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues." International Journal of Biological Macromolecules 112 (2018): 33-45. Barrabés, S.; Llop, E.; Ferrer-Batallé, M.; Ramírez, M.; Aleixandre, R.N.; Perry, A.S.; de Llorens, R.; Peracaula, R. "Analysis of urinary PSA glycosylation is not indicative of high-risk prostate cancer." Clinica Chimica Acta 470 (2017): 97-102. Ferrer-Batallé M; Llop E; Ramírez M; Aleixandre RN; Saez M; Comet J; De Llorens R; Peracaula R "Comparative study of blood-based biomarkers, α2,3-sialic acid PSA and PHI, for high risk prostate cancer detection." International Journal of Molecular Sciences 18 (2017): 845-. Farina-Gomez, N.; Barrabés, S.; Gomez-Lopez, J.E.; Gonzalez, M.; Puerta, A.; Navarro-Calderon, D.; Albers-Acosta, E.; Olivier, C.; Diez-Masa, J.C.; Peracaula, R.; de Frutos, M. "Sample preparation of serum to allow capillary electrophoresis analysis of prostate specific antigen isoforms." Journal of Pharmaceutical and Biomedical Analysis 134 (2017): 220-227. Barrabés, S.; Farina-Gomez, N.; Llop, E.; Puerta, A.; Diez-Masa, J.C.; Perry, A.; de Llorens, R.; de Frutos, M.; Peracaula, R. "Comparative analysis of prostate-specific antigen by two-dimensional gel electrophoresis and capillary electrophoresis." Electrophoresis 38 (2017): 408-416. Llop, E.; Ferrer-Batallé, M.; Barrabés, S.; Guerrero, P.E.; Ramírez, M.; Saldova, R.; Rudd, P.M.; Aleixandre, R.N.; Comet, J.; de Llorens, R.; Peracaula, R. "Improvement of Prostate Cancer diagnosis by detecting PSA glycosylation-specific changes." Theranostics 6 (2016): 1190-1204. Ferri MJ; Saez M; Figueras J; Fort E; Sabat M; López-Ben S; De Llorens R; Aleixandre RN; Peracaula R "Improved pancreatic adenocarcinoma diagnosis in jaundiced and non-jaundiced pancreatic adenocarcinoma patients through the combination of routine clinical markers associated to pancreatic adenocarcinoma pathophysiology." PLoS One 11 (2016): e0147214.-. Balmaña, Meritxell; Giménez, Estela; Puerta, Ángel; Llop, Esther; Figueras, Joan; Fort, Esther; Sanz-Nebot, Victòria; Bolós, Carme de; Rizzi, Andreas; Barrabés, Sílvia; Frutos, Mercedes de; Peracaula, Rosa "Increased α1-3 fucosylation of α-1-acid glycoprotein (AGP) in pancreatic cancer." Journal of Proteomics 132 (2016): 144-154. Bassagañas, S; Allende, H; Cobler, L; Ortiz, M.R; Llop, E; de Bolós, C; Peracaula, R. "Inflammatory citokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines." Cytokine 75 (2015): 197-206. Giménez, Estela; Balmaña, Meritxell; Figueras, Joan; Fort Martorell, Esther; Bolòs, Carme de; Sanz Nebot, María Victoria; Peracaula Miró, Rosa; Rizzi, Andreas "Quantitative analysis of N-glycans from human alfa-acid-glycoprotein using stable isotope labeling and zwitterionic hydrophilic interaction capillary liquid chromatography electrospray mass spectrometry as tool for pancreatic disease diagnosis." Analytica Chimica Acta 866 (2015): 59-68. Meritxell Balmaña; Ariadna Sarrats; Esther Llop; Sílvia Barrabés; Radka Saldova; Maria-José Ferri; Joan Figueras; Esther Fort; Rafael de Llorens; Pauline M Rudd; Rosa Peracaula "Identification of potential pancreatic cancer serum markers: increased sialyl-Lewis X on ceruloplasmin." Clinica Chimica Acta 442 (2015): 56-62. Bassagañas S; Pérez-Garay M; Peracaula R; "Cell surface sialic acid modulates extracellular matrix adhesion and migration in pancreatic adenocarcinoma cells." Pancreas 43 (2014): 109-117. Saldova R, Piccard H, Pérez-Garay M, Harvey DJ, Struwe WB, Galligan MC, Berghmans N, Madden SF, Peracaula R, Opdenakker G, Rudd PM. "Increase in sialylation and branching in the mouse serum N-glycome correlates with inflammation and ovarian tumour progression.." PLoS One 8 (2013): e71159-. Pérez-Garay M; Arteta B; Llop E; Cobler L; Pagès L; Ortiz R; Ferri MJ; de Bolós C; Figueras J; de Llorens R; Vidal-Vanaclocha F; Peracaula R. "α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues." The International Journal of Biochemistry and Cell Biology 45 (2013): 1748-1757. Saldova R; Dempsey E; Pérez-Garay M; Mariño K; Watson JA; Blanco-Fernández A; Struwe WB; Harvey DJ; Madden SF; Peracaula R; McCann A; Rudd PM "5-AZA-2'-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer. ." Epigenetics 6 (2011): 1362-1372. Padró,M.;Mejías-Luque,R.;Cobler,L.;Garrido,M.; Pérez,M.;Puig,S.;Peracaula,R;Bolós,C. "Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells." Glycoconjugate Journal 28 (2011): 99-110. Barrabés, S.; Sarrats, A.; Fort, E.; Rudd, P.M.; Llorens, R.; Peracaula, R. "Effect of sialic acid content on glycoprotein pI analyzed by two-dimensional electrophoresis." Electrophoresis 31 (2010): 2903-2912. Sarrats, A.; Saldova, R.; Pla, E.; Harvey, D.; Struwe, W.B.; Llorens, R.; Rudd, P.M.; Peracaula, R. "Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic pancreatitis." Proteomics. Clinical applications 4 (2010): 432-448. Pérez,M.;Arteta,B.;Pagès, Ll.;de Llorens, R.;de Bolós, C.;Vidal-Vanaclocha, F.;Peracaula, R. "Alpha2,3-Sialyltransferase ST3Gal III Modulates Pancreatic Cancer Cell Motility and Adhesion In Vitro and Enhances Its Metastatic Potential In Vivo." PLoS One 5 (2010): e12524-. Sarrats, A.; Saldova, R.; Comet, J.; O'Donoghue, N.; Llorens, R.; Rudd, P.M.; Peracaula, R. "Glycan characterization of total PSA 2-DE subforms from serum and seminal plasma." Omics-a Journal Of Integrative Biology 14 (2010): 465-474. Sarrats, A.; Comet, J.; Tabarés, G.; Ramirez, M.; Aleixandre, R.N.; Llorens, R.; Peracaula, R. "Differential percentage of serum prostate-specific antigen subforms suggests a new way to improve prostate cancer diagnosis ." Prostate 70 (2010): 1-9. Peracaula, R.; Barrabés, S.; Sarrats, A.; Rudd, P.M.; Llorens, R. "Altered glycosylation in tumours focused to cancer diagnosis." Disease Markers 25 (2008): 207-218. Barrabés, S.; Pages, L.; Radcliffe, C.M.; Tabares, G.; Fort, E.; Royle, L.; Harvey, D.J.; Moenner, M.; Dwek, R.A.; Rudd, P.M.; Llorens, R.; Peracaula, R. "Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer." Glycobiology 17 (2007): 388-400. Peracaula, R. "Altered glycosylation in tumour proteins: biological implications." Afinidad 64 (2007): 346-355. Tabarés, G.; Jung, K.; Reiche, J.; Stephan, C.; Lein, M.; Peracaula, R.; Llorens, R.; Hösel, W. "Free PSA forms in prostatic tissue and sera of prostate cancer patients: analysis by 2-DE and western blotting of immunopurified samples." Clinical Biochemistry 40 (2007): 343-350. Tabarés, G.; Radcliffe, C.; Barrabés, S.; Ramírez, M.; Aleixandre, R.N.; Hoesel, W.; Dwek, R.; Rudd, P.; Peracaula, R.; Llorens, R. "Different glycan structures in prostate-specific antigen from prostate cancer sera in relation to seminal plasma PSA." Glycobiology 16 (2006): 132-145. Peracaula, R.; Tabarés, G.; López-Ferrer, A.; Brossmer, R.; Bolós, C.; Llorens, R. "Role of sialyltransferases involved in the biosynthesis of Lewis antigens in human pancreatic tumour cells ." Glycoconjugate Journal 22 (2005): 135-144. Peracaula, R.; Tabarés, G.; Royle, L.; Harvey, D.; Dwek, R.; Rudd, P.; Llorens, R. "Altered glycosylation pattern allows the distinction between Prostate Spedific Antigen (PSA) from normal and tumour origins." Glycobiology 13 (2003): 457-470. Peracaula, R.; Royle, L.; Tabarés, G.; Mallorquí-Fernández, G.; Barrabés, S.; Harvey, D.; Dwek, R.; Rudd, P.; Llorens, R. "Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states." Glycobiology 13 (2003): 227-244. Pous, J.; Mallorquí-Fernández, G.; Peracaula, R.; Terzyan, S.S.; Futami, J.; Tada, H.; Yamada, H.; Seno, M.; Llorens, R.; Gomis-Rüth, FX.; Coll, M. "Three-dimensional structure of human RNase 1ΔN7 at 1.9 Å resolution ." Acta Crystallographica Section D-Biological Crystallography 57 (2001): 498-505. Peracaula, R.; Cleary, K.R.; Lorenzo, J.; Llorens, R.; Frazier, M.L. "Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma." Cancer 89 (2000): 1252-1258. Fernández-Salas, E.; Peracaula, R.; Frazier, M.L.; Llorens, R. "Ribonucleases expressed by human pancreatic adenocarcinoma cell lines." European Journal of Biochemistry 267 (2000): 1484-1494. Mallorquí-Fernández, G.; Pous, J.; Peracaula, R.; Aymami, J.; Maeda, T.; Tada, H.; Yamada, H.; Seno, M.; Llorens, R.; Gomis-Rüth, FX.; Coll, M. "Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution." Journal of Molecular Biology 300 (2000): 1297-1307. Terzyan, S.S.; Peracaula, R.; de Llorens, R.; Tsushima, Y.; Yamada, H.; Seno, M.; Gomis-Rüth; FX., Coll, M. "The three dimensional structure of recombinant human RNase 4: Unliganded and complexed with d(Up), reveals the bases for its uridine selectivity.." Journal of Molecular Biology 285 (1999): 205-214. Brosa, C.; Zamora, I.; Terricabras, E.; Soca, L.; Peracaula, R.; Rodríguez-Santamarta, C. "Synthesis and molecular modeling: related approaches to progress in brassinosteroid research.." Lipids 32 (1997): 1341-1347. Brosa, C.; Nusimovich, S.; Peracaula, R. "Synthesis of new brassinosteroids with potential activity as antiecdysteroids.." Steroids 59 (1994): 463-467. Brosa, C.; Peracaula, R.; Puig, R.; Ventura, M. "Use of dihydroquinidine 9-O-(9'-phenanthryl) ether in osmium-catalyzed asymmetric dihydroxylation in the synthesis of brassinosteroids." Tetrahedron Letters 33 (1992): 7057-7060.
Peracaula R; Sarrats A; Balmaña M, Llop E; Barrabés S; Saldova R; Comet J, Figueras J, Rudd PM, Llorens R "Altered Glycosylation of Serum Glycoproteins as Tumour Biomarkers - the Case of Prostate-specific Antigen in Prostate Cancer and the Case of Acute-phase Proteins in Pancreatic Adenocarcinoma." European Journal of Cancer 48, suppl. 5 (2012): S25-S288.
Peracaula, R.; Rudd, P.M.; Sarrats, A. "Liver proteins as sensor of human malignancies and inflammation." Proteomics. Clinical applications 4 (2010): 426-431.
Bassagañas S; Carvalho S; Dias A; Pérez-Garay M; Ortiz RM; Figueras J; Reis CA; Pinho SS; Peracaula R "Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of &a.2&b.1 integrin and E-cadherin function." PLoS One (2014): -.