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Dra.  PUIG MIQUEL, MARIA TERESA

Personal page

Category
PROFESSORA CATEDRÀTICA
Department
CIÈNCIES MÈDIQUES
Area of knowledge
FISIOLOGIA
Research group
Grup de Recerca en Noves Dianes Terapèutiques (TargetsLab)
ORCID PRC:
0000-0003-2715-7043

Brief CV

Ph.D. student at the group of Jordi Barquinero in the Institute of Oncology Research (Hospital Duran y Reynalds, Barcelona). In 2003, Dr. Teresa Puig was awarded with a nationally-funded-2-year position as a scientist at the Girona Research Institute (MEC; EX2003-1020) to develop her research on Cancer Drug Development in the Division of Medical Oncology at the Catalan Institute of Oncology (Dr. Josep Trueta Hospital) in Girona. In 2006, she was awarded again by the Fund for Scientific Research “Programa Juan de la Cierva” (Junior PI; JCI-2005-1616-1) from Ministry of Science and Technology of Spain to direct the project: “Study and Characterization of the Therapeutic Potential of Novel Fatty Acid Synthase (FASN) Inhibitors in Breast Cancer”. As a Junior PI, she got public and private Grants from the Spanish Instituto de Salud Carlos III (FIS PI082031; RD06-0020-0028; FIS PI11/00692), the Spanish Ministerio de Ciencia y Innovación (MICCN, CIT- 090000-2008-10) and the Spanish Society of Medical Oncology. Results had led to the identification of compounds with relevant anticancer activity, which has resulted in the application for two national patents (P2 01030239, P201231228) and one international patent (P824EP00) transferred to the industry Italfármaco SA in 2009 and three industry contracts with pharmaceutical companies (Wyeth, Pfyzer and Italfármaco). Dr. Puig received three awards in her Junior PI period. Dr. Puig also mentored graduate and post-graduate students from the School of Sciences (University of Girona, Spain) and she was Professor of Biochemistry and Molecular Biology between 2001 and 2008. In 2009 she promoted for a position as Associate Professor in the Medical Sciences Dept. (University of Girona) and as Director of the New Therapeutic Targets Lab (TargetsLab) group.

Her lab operates at the interface between biology, engineering and medicine, where they seek to understand molecular and genetic causes of acquired resistance in breast cancer with the aim to find novel biomarkers and improved therapeutic strategies in this setting. By the nature of her work she has a strong history of with basic science, biomedical engineering, translational researchers and clinicians.  

Research Interests of the Group

The current efforts of TargetsLab are focused on the design and utilization of molecular and technological tools for targeting particularly breast cancer progression and recurrence and misregulated wound healing processes. For studying and understanding such complex processes we focused our efforts in:

  1. Preclinical (sensitive and chemoresistant cellular models, tumoroids and ortoxenopatients) and clinical (patient tumor samples) models for the evaluation of novel biomarkers (proteins, genes or epigenetic markers) to develop and test synthetic anti-cancer compounds (or novel treatment approaches) for those patients who have progressed to breast cancer.
  1. Design and manufacture several three-dimensional (3D) structures to implement 3D culture of preclinical TNBC models (cells and tumoroids) to enrich and isolate breast cancer stem cells (BCSCs).

Research projects financed in the last five years

Research projects:

TITLE: Pre-clinical characterization of fatty acid synthase (FASN) inhibition in anti-HER2 drug-resistant models

FINANCING ENTITY: Instituto de Salud Carlos III (PI11/00692)                                                     

DURATION:  3 year                     FROM:2012        UNTIL:2015

PRINCIPAL INVESTIGATOR: Teresa Puig

 

TITLE: Grup consolidate: Research group in technological innovation to productive systems.

FINANCING ENTITY: Direcció General de Recerca. Generalitat of Catalunya (SGR2017-00385)                                                   

DURATION:  3 year                     FROM:2014        UNTIL:2016

PRINCIPAL INVESTIGATOR: Joaquim Ciurana

 

TITLE: Development of new antitumor drugs with high efficiency and specificity and low toxicity for oral administration

FINANCING ENTITY:  Ministry of Economy and Competitiveness (RTC-2014-2589-1)

DURATION: 3 years                    FROM: 2015       UNTIL: 2018

PRINCIPAL INVESTIGATOR: Teresa Puig

 

TITLE: The inhibition of the lipogenic enzyme fatty acid synthase (FASN) as a new therapeutic strategy for the treatment of triple negative breast cancer

FINANCING ENTITY: Fundación Ramón Areces

DURATION:  3 year                     FROM:2015        UNTIL:2018

PRINCIPAL INVESTIGATOR: Teresa Puig

 

TITLE: Preclinical characterization of the inhibition of fatty acid metabolism in triple negative breast cancer models

FINANCING ENTITY: Instituto de Salud Carlos III (PI14/00329)

DURATION: 3 years                    FROM:  2015        UNTIL:2018

PRINCIPAL INVESTIGATOR: Teresa Puig

 

Contracts:

TITLE: Fatty Acid Synthase (FASN) inhibition: an alternative strategy to overcome resistance to EGFR Tyrosine Kinase Inhibitors in Non-squamous Non-Small Cell Lung Cancer

FINANCING ENTITY: AstraZeneca Co.

DURATION: 1 year                   FROM:  2017        UNTIL:2018

PRINCIPAL INVESTIGATOR: Teresa Puig

TITLE: Fatty Acid Synthase (FASN) inhibition: an alternative strategy to overcome resistance to EGFR Tyrosine Kinase Inhibitors in Non-squamous Non-Small Cell Lung Cancer (II)

FINANCING ENTITY: AstraZeneca Co.

DURATION: 3 years                    FROM:  2019       UNTIL:2021

PRINCIPAL INVESTIGATOR: Teresa Puig

 

Stays in foreign centers

Visitant Professor at Perlmutter Cancer Center in Langone Medical Center and University of New York, New York, USA 2018.

Ph.D Student at Centro de Investigaciones Medioambientals. Energéticas y Tecnológicas (CIEMAT) / Hematopoiesis Group, Madrid, Spain 1999

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