Rebecca Martínez-Moreno; David Carreras; Georgia Sarquela-Brugada; Guillermo J. Pérez; Elisabet Selga ; Fabiana S. Scornik; Ramon Brugada "Loss of sodium current caused by a Brugada syndrome-associated variant is determined by patient-specific genetic background." Heart Rhythm (2023): -. Escribá R, Larrañaga-Moreira JM, Richaud-Patin Y, Pourchet L, Lazis I, Jiménez-Delgado S, Morillas-García A, Ortiz-Genga M, Ochoa JP, Carreras D, Pérez GJ, de la Pompa JL, Brugada R, Monserrat L, Barriales-Villa R, Raya A "iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy.." Circulation Research 133(2):108-119 (2023): -. Vallverdú-Prats, M.; Carreras, D.; Pérez, G.J.; Campuzano, O.; Brugada, R.; Alcalde, M. "Alterations in calcium handling are a common feature in an arrhythmogenic cardiomyopathy cell model triggered by desmosome genes loss." International Journal of Molecular Sciences 24 (2023): 2109-. David Carreras, Rebecca Martinez-Moreno, Mel·lina Pinsach-Abuin, Manel M. Santafe, Pol Gomà, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Pérez, Sara Pagans "Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle." International Journal of Molecular Sciences 22 (2021): 2755-. Rebecca Martinez-Moreno; Elisabet Selga; Helena Riuró; David Carreras; Mered Parnes; Chandra Srinivasan; Michael F. Wangler; Guillermo J. Pérez; Fabiana S. Scornik; Ramon Brugada "An SCN1B Variant Affects Both Cardiac-Type (NaV1.5) and Brain-Type (NaV1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders." Frontiers in Cell and Developmental Biology 8 (2020): 1-17. Yeste, M.; Llavanera, M.; Scornik, F.; Pérez, G.; Puig-Parri, J.; Brugada, R.; Bonet, S.; Pinart, E. "Elucidating the role of K+ channels during in vitro capacitation of boar spermatozoa: do SLO1 channels play a crucial role?." International Journal of Molecular Sciences 20 (2019): 6330-. Santori M; Gil R;, Blanco-Verea A; Riuró H; Díaz-Castro Ó; López-Abel B; Brugada R; Carracedo Á; Pérez GJ; Scornik FS; Brion M9. "Sudden infant death as the most severe phenotype caused by genetic modulation in a family with atrial fibrillation." Forensic Science International 43 (2019): -. Cuyàs E; Gumuzio J; Lozano-Sánchez J; Carreras D; Verdura S; Llorach-Parés L; Sanchez-Martinez M; Selga E; Pérez GJ; Scornik FS; Brugada R; Bosch-Barrera J; Segura-Carretero A; Martin ÁG; Encinar JA; Menendez JA. "Extra virgin olive oil contains a phenolic inhibitor of the histone demethylase LSD1/KDM1A." Nutrients 11 (2019): 1656-. Wangüemert Pérez F; Hernández Afonso JS; Groba Marco MDV; Caballero Dorta E; Álvarez Acosta L; Campuzano Larrea O; Pérez G; Brugada Terradellas J; Brugada Terradellas R. "Flecainide Reduces Ventricular Arrhythmias in Patients With Genotype RyR2-positive Catecholaminergic Polymorphic Ventricular Tachycardia.." Revista Española de Cardiologia (2018): -. Elisabet Selga; Franziska Sendfeld; Rebecca Martinez-Moreno; Claire N Medine; Olga Tura-Ceide; Ian Wilmut; Guillermo J Pérez; Fabiana S Scornik; Ramon Brugada; Nicholas L Mills "Sodium channel current loss of function in induced pluripotent stem cell-derived cardiomyocytes from a Brugada syndrome patient." Journal of Molecular and Cellular Cardiology 114 (2017): 10-19. Wangüemert, F; Bosch Calero, C; Pérez, C; Campuzano, O; Beltran-Alvarez, P; Scornik, FS; Iglesias, A; Berne, P; Allegue, C; Ruiz Hernandez, P; Brugada, J; Pérez, GJ; Brugada, R "Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia." Heart Rhythm 12 (2015): 1636-1643. Peeters, U; Scornik, F; Riuró, H; Pérez, G; Komurcu-Bayrak, E; Van Malderen, S; Pappaert, G; Tarradas, A; Pagans, S; Daneels, D; Breckpot, K; Brugada, P; Bonduelle, M; Brugada, R; Van Dooren, S "Contribution of cardiac sodium channel β-subunit variants to Brugada syndrome." Circulation Journal 79 (2015): 2118-2129. Riuró, H; Campuzano, O; Arbelo, E; Iglesias, A; Batlle, M; Pérez-Villa, F; Brugada, J; Pérez, GJ; Scornik, FS; Brugada, R. "A missense mutation in the sodium channel β1b subunit reveals SCN1B as a susceptibly gene underlying LQT Syndrome." Heart Rhythm 11 (2014): 1202-1209. Bosch Calero, C; Selga, E; Brugada, R; Scornik, FS; Perez, GJ. "The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels." Channels 8 (2014): 95-102. Beltran-Alvarez P; Espejo A; Schmauder R; Beltran C; Mrowka R; Linke T; Batlle M; Pérez-Villa F; Pérez GJ; Scornik FS; Benndorf K; Pagans S; Zimmer T; Brugada R. "Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel.." Febs Letters 587 (2013): 3159-3165. Riuró, H; Beltran-Alvarez, P; Tarradas, A; Selga, E; Campuzano, O; Vergés, M; Pagans, S; Iglesias, A; Brugada, J; Brugada, P; Vázquez, FM; Pérez, GJ; Scornik, FS; Brugada R. "A missense mutation in the sodium channel β2 subunit reveals SCN2B as a new candidate gene for Brugada Syndrome." Human Mutation 34 (2013): 961-966. Selga,E; Pérez-Serra, A; Moreno-Asso, A; Anderson, S; Thomas, K; Desai, M; Brugada, R; Pérez, GJ; Scornik, FS. "Molecular heterogeneity of large-conductance calcium-activated potassium channels in canine intracardiac ganglia." Channels 7 (2013): 322-328. Scornik FS; Bucciero RS; Wu Y; Selga E; Bosch Calero C; Brugada R; Perez GJ. "DiBAC4(3) hits a 'sweet spot' for the activation of arterial large-conductance Ca2+-activated potassium (BK) channels independently of the β1 subunit." American Journal of Physiology. Heart and Circulatory Physiology 304 (2013): H1471-H1482. Guillermo J. Pérez; Mayurika Desai; Seth Anderson; Fabiana S. Scornik "Large conductance calcium-activated potassium (BK) current modulates excitability in isolated canine intracardiac neurons." American Journal of Physiology. Cell Physiology 304 (2013): C280-C286. Anna Tarradas; Elisabet Selga; Pedro Beltran-Alvarez, Alexandra Pérez-Serra; Helena Riuró; Ferran Picó; Anna Iglesias; Oscar Campuzano; Victor Castro-Urda; Ignasio Fernández-Lozano; Guillermo J. Pérez; Fabiana S. Scornik FS; "A Novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada Syndrome." PLoS One 8 (2013): Epub-. Cordeiro, Jonathan M. ;Perez, Guillermo J. ;Schmitt, Nicole ;Pfeiffer, Ryan ;Nesterenko, Vladislav V. ;Burashnikov, Elena ;Veltmann, Christian ;Borggrefe, Martin ;Wolpert, Christian ;Schimpf, Rainer ;Antzelevitch, Charles "Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2." Canadian Journal of Physiology and Pharmacology 88 (2010): 1181-1190. Eyal Nof; Jonathan M. Cordeiro; Guillermo J. Pérez; Fabiana S. Scornik; Kirstine Calloe; Barry Love; Elena Burashnikov; Gabriel Cáceres; Moshe Gunsburg; Charles Antzelevitch "A Common Single Nucleotide Polymorphism Can Exacerbate Long QT Type 2 Syndrome Leading to Sudden Infant Death." Circulation : Cardiovascular Genetics 3 (2010): 199-206. Liang, Lei; Pan, Qin; Liu, Yi; Chen, Huaizhi; Li, Jun; Brugada, Ramon; Brugada, Pedro; Hong, Kui; Perez, Guillermo J.; Zhao, Cuimei; Qi, Jie; Zhang, Yangyang; Peng, Luying; Li, Li; Chen, Yi-Han "High sensitivity of the sheep pulmonary vein antrum to acetylcholine stimulation." Journal of Applied Physiology 105 (2008): 293-298. He, Yusong; Pan, Qin; Li, Jun; Chen, Huaizhi; Zhou, Qinshu; Hong, Kui; Brugada, Ramon; Perez, Guillermo J.; Brugada, Pedro; Chen, Yi-Han "Kir2.3 knock-down decreases I-K1 current in neonatal rat cardiomyocytes." Febs Letters 582 (2008): 2338-2342. Fabiana S. Scornik; Mayurika Desai; Ramón Brugada; Alejandra Guerchicoff; Guido D. Pollevick; Charles Antzelevitch; Guillermo J. Pérez "Functional expression of 'cardiac-type' Nav1.5 sodium channel in canine intracardiac ganglia." Heart Rhythm 3 (2006): 842-850. Pérez GJ "Dual effect of tamoxifen on arterial KCa channels does not depend on the presence of the beta1 subunit.." Journal of Biological Chemistry 280 (2005): 21739-21747. Di Diego JM; Cordeiro JM; Goodrow RJ; Fish JM; Zygmunt AC; Pérez GJ; Scornik FS; Antzelevitch C. "Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males." Circulation 106 (2002): 2004-2011. Wellman, G. C.; Nathan, D. J.; Saundry, C. M.; Perez, G.; Bonev, A. D.; Penar, P. L.; Tranmer, B. I.; Nelson, M. T. "Ca2+ sparks and their function in human cerebral arteries.." Stroke 33 (2002): 802-808. Pozo MJ; Pérez GJ; Nelson MT; Mawe GM. "Ca(2+) sparks and BK currents in gallbladder myocytes: role in CCK-induced response." American Journal of Physiology. Gastrointestinal and Liver Physiology 282 (2002): G165-G174. Perez, G. J.; Bonev, A. D.; Nelson, M. T. "Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle." American Journal of Physiology. Cell Physiology 281 (2001): C1769-C1775. Brenner, R.; Perez, G. J.; Bonev, A. D.; Eckman, D. M.; Kosek, J. C.; Wiler, S. W.; Patterson, A. J.; Nelson, M. T.; Aldrich, R. W. "Vasoregulation by the beta 1 subunit of the calcium-activated potassium channel." Nature 407 (2000): 870-876. Perez, G. J.; Bonev, A. D.; Patlak, J. B.; Nelson, M. T. "Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries." Journal of General Physiology 113 (1999): 229-237. Pérez G; Toro L. "Differential modulation of large-conductance KCa channels by PKA in pregnant and nonpregnant myometrium." American Journal of Physiology (1898-1976) 266 (1994): C1459-C1463. Perez, G. ;Lagrutta, A. ;Adelman, J. P. ;Toro, L. "Reconstitution of expressed KCa channels from Xenopus oocytes to lipid bilayers." Biophysical Journal 66 (1994): 1022-1027. Anwer K; Oberti C; Perez GJ; Perez-Reyes N; McDougall JK; Monga M; Sanborn BM; Stefani E; Toro L "Calcium-activated K+ channels as modulators of human myometrial contractile activity." American Journal of Physiology (1898-1976) 265 (1993): C976-C985. Pérez GJ; Toro L; Erulkar SD; Stefani E. "Characterization of large-conductance, calcium-activated potassium channels from human myometrium.." American Journal of Obstetrics and Gynecology 168 (1993): 652-660. Jorge A Colombo; Gerard Charton; Guillermo Pérez "Development of an 'in vitro' stage prior to neural transplantation: substrate adhesion of cell aggregates." Acta Physiologica et Pharmacologica Latinoamericana 40 (1990): 37-43.
Franziska Sendfeld; Elisabet Selga; Fabiana S. Scornik: Guillermo J. Pérez; Nicholas L. Mills; Ramon Brugada "Experimental Models of Brugada syndrome." International Journal of Molecular Sciences 20 (2019): 2123-. Campuzano O; Beltrán-Alvarez P; Iglesias A; Scornik F; Pérez G; Brugada R "Genetics and cardiac channelopathies." Genetics in Medicine 12 (2010): 260-267. Antzelevitch C; Belardinelli L; Wu L; Fraser H; Zygmunt AC; Burashnikov A; Di Diego JM; Fish JM; Cordeiro JM; Goodrow RJ Jr; Scornik F; Perez G. "Electrophysiologic properties and Antiarrhythmic actions of a novel antianginal agent." Journal of Cardiovascular Pharmacology and Therapeutics 9 (2004): S65-S83. Jaggar, J. H. ;Wellman, G. C. ;Heppner, T. J. ;Porter, V. A. ;Perez, G. J. ;Gollasch, M. ;Kleppisch, T. ;Rubart, M. ;Stevenson, A. S. ;Lederer, W. J. ;Knot, H. J. ;Bonev, A. D. ;Nelson, M. T. "Ca2+ channels, ryanodine receptors and Ca2+-activated K+ channels: a functional unit for regulating arterial tone." Acta Physiologica Scandinavica 164 (1998): 577-587.