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Grup de Recerca en Neurobiologia Cel·lular i Molecular

Potenciació cognitiva i plasticitat neural

  • Huguet G; Kádár E; Serrano N; Tapias-Espinosa C; García-Brito S; Morgado-Bernal I; Aldavert-Vera L;Segura-Torres P. (2019). Rewarding deep brain stimulation at the medial forebrain bundle favours avoidance conditioned response in a remote memory test, hinders extinction and increases neurogenesis. Behavioural BrainResearch
  • Huguet, G.; Temel, Y.; Kádár, E; Pol. S.; Casaca-Carreira, J.; Segura-Torres, P. & Jahanshahi, A. (2019). Altered expression of dopaminergic cell fate regulating genes prior to manifestation of symptoms in a transgenic rat model of Huntington's disease. Brain Research (1712): 101-108. https://doi.org/10.1016/j.brainres.2019.01.041.
  • Garcia-Brito, S.; Aldavert-Vera, L.; Huguet, G.; Alvarez, A.; Kádár, E. & Segura-Torres, P. (2018). Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas. Behavioural Brain Research (353): 21-31. https://doi.org/10.1016/j.bbr.2018.05.028.
  • Kádár, E.; Vico Varela, E.; Aldavert-Vera, L.; Huguet, G.; Morgado-Bernal, I. & Segura-Torres, P. (2018). Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas. BMC Neuroscience 19:48. https://doi.org/10.1186/s12868-018-0449-5.
  • Tapias-Espinosa, C.; Kádár, E.& Segura-Torres, P. (2018). Spaced sessions of avoidance extinction reduce spontaneous recovery and promote infralimbic còrtex activation. Behavioural Brain Research  (336): 59-66. https://doi.org/10.1016/j.bbr.2017.08.025.
  • Huguet, G.; Kádár, E.; Temel, Y. & Wei Lim, L. (2017). Electrical stimulation normalizes c-Fos expression in the deep cerebellar nuclei of depressive-like rats: implication of Antidepressant activity. Cerebellum (16): 398-410. http://doi.org/10.1007/s12311-016-0812-y.
  • Kádár, E.; Vico-Varela, E.; Aldavert-Vera, L.; Huguet. G.; Morgado-Bernal, I. & Segura-Torres, P. (2016). Increase in c-Fos and Arc protein in retrosplenial cortex after memory-improving lateral hypothalamic electrical stimulation treatment. Neurobiology of Learning and Memory (128): 117-124. http://doi.org/10.1016/j.nlm.2015.12.012.
  • Wei Lim, L.; Prickaerts, J.; Huguet, E.; Kádár, E.; Hartung, H.; Sharp, T. & Temel, Y. (2015). Electrical stimulation alleviates depressive-like behaviors of rats: Investigation of brain targets and potential mechanisms. Translational Psychiatry (5): e535. https://dx.doi.org/10.1038%2Ftp.2015.24.
  • Kádár, E.; Ramoneda, M.; Aldavert-Vera, L.; Huguet, G.; Morgado-Bernal, I. & Segura-Torres, P. (2014).Rewarding brain stimulation reverses the disruptive effect of amygdala damage on emotional learning. Behavioural Brain Research (274): 43-52. https://doi.org/10.1016/j.bbr.2014.07.050

Dianes terapèutiques i marcadors pronòstic en ictus

  • Castellanos, M.; van Eendenburg, C.; Gubern, C.; Kádár, E.; Huguet, G.; Puig, J.; Sobrino, T.; Blasco, G., Serena, J. & Sánchez, J.M. (2018). Low Levels of Caveolin-1 Predict Symptomatic Bleeding After Thrombolytic Therapy in Patients With Acute Ischemic Stroke. Stroke (49): 1525–1527.
  • Comajoan, P.; Gubern, C.; Huguet, G.;Serena, J; Kádár, E. & Castellanos, M. (2018). Evaluation of common housekeeping proteins under ischemic conditions and/or rt-PA treatment in bEnd.3 cells. Journal of Proteomics (184):10-15. https://doi.org/10.1016/j.jprot.2018.06.011.
  • Castellanos, M.; van Eendenburg, C.; Gubern, C. & Sanchez, JM. (2016). Ethyl-bridged hybrid column as an eficient alternative for HPLC analysis of plasma amino acids by pre-colum derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl cabamate. Journal of chromatography B Analytical technologies in the biomedical and life sciences (1029): 137-144. https://doi.org/10.1016/j.jchromb.2016.07.004.
  • Camós, S.; Guber, C.; Sobrado, M.; Rodríguez, R.; Romera, VG.; Moro, MA.; Lizasoain, I.; Serena, J.; Mallolas, J. & Castellanos, M. (2014). The high-mobility group I-Y transcription factor is involved in cerebral ischemia and modulates the expression of angiogenic proteins. Neuroscience (269): 112-130. https://doi.org/10.1016/j.neuroscience.2014.03.036.
  • Mallolas, J.; Rodríguez, R.; Gubern, C.; Camós, S.; Serena, J. & Castellanos, M. (2014). A polymorphism in the promoter region of the survivin gene is related to hemorrhagic transformation in patients with acute ischemic stroke. Neuromolecular Medicine (16): 856-861. https://doi.org/10.1007/s12017-014-8333-7.

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