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Curs acadèmic:
2025
Descripció:
Síntesi orgànica: estratègies i control. Formació d'enllaços mitjançant catàlisi per metalls de transició. Estratègies de síntesi en fase sòlida.
Crèdits:
6
Professor responsable:
Agustí Lledó Ponsati

Grups

Grup F

Durada:
Semestral, 1r semestre
Professorat:
Agustí Lledó Ponsati  / Marta Planas Grabuleda
Idioma de les classes:
Anglès (100%)

Competències

  • CB1 - Que els estudiants sàpiguen aplicar els coneixements adquirits i la seva capacitat de resolució de problemes en entorns nous o poc coneguts dins de contextos més amplis (o multidisciplinaris) relacionats amb la seva àrea d'estudi.
  • CB2 - Que els estudiants siguin capaços d'integrar coneixements i enfrontar-se a la complexitat de formular judicis a partir d'una informació que, sent incompleta o limitada, inclogui reflexions sobre les responsabilitats socials i ètiques vinculades a l'aplicació dels seus coneixements i judicis.
  • CB3 - Que els estudiants sàpiguen comunicar les seves conclusions i els coneixements i raons últimes que les sustenten a públics especialitzats i no especialitzats d'una manera clara i sense ambigüitats, fent servir com a llengua vehicular l'anglès.
  • CE10 - Identificar els conceptes i principis fonamentals de la síntesi orgànica i avaluar les noves tendències metodològiques per a la síntesi eficient de compostos químics i molècules bioactives.

Continguts

1. Retrosynthetic analysis: 1.1 General principles of retrosynthetic analysis. 1.2 Functional group interconversions and protecting groups. 1.3 Disconnections - The synthon approach 1.4 Transform based strategies. 1.5 Stereoselectivity and asymmetric synthesis

2. Solid-phase synthetic strategies: 2.1. General aspects 2.1.1. An overview on solid supports 2.1.2. Linkers 2.1.3. Protecting groups 3.1.4. Reaction monitoring in solid-phase synthesis 3.2. Solid-phase synthesis of small organic compounds and biomolecules

Activitats

Tipus d’activitat Hores amb professor Hores sense professor Hores virtuals amb professor Total
Prova d'avaluació 6,00 35,00 0 41,00
Resolució d'exercicis 10,00 19,00 0 29,00
Sessió expositiva 39,00 26,00 0 65,00
Sessió participativa 6,00 9,00 0 15,00
Total 61,00 89,00 0 150

Bibliografia

  • Wyatt, Paul (cop. 2007 ). Organic synthesis : strategy and control . Hoboken, NJ: John Wiley. Catàleg
  • Warren, Stuart (2009 ). Workbook for organic synthesis : the disconnection approach (2nd ed.). Chichester [etc.]: Wiley. Catàleg
  • Wyatt, Paul (2008 ). Workbook for organic synthesis : strategy and control . Chichester [etc.]: John Wiley & Sons. Catàleg
  • Warren, Stuart (2009 ). Workbook for organic synthesis : the disconnection approach (2nd ed.). Chichester [etc.]: Wiley. Catàleg
  • Lloyd-Williams, Paul (1997 ). Chemical approaches to the synthesis of peptides and proteins . Boca Raton [Fla.] [etc.]: CRC Press. Catàleg
  • Kates, Steven A. Albericio Palomera, Fernando (cop. 2000 ). Solid phase synthesis : a practical guide . Basel (Switzerland): Marcel Dekker. Catàleg

Avaluació i qualificació

Activitats d'avaluació:

Descripció de l'activitat Avaluació de l'activitat % Recuperable
Exercises related to the topics of the course to be solved in class or at home Students, working in small groups, will be asked to solve problem sets in class or at home. These problem sets will be related to the topics of the course. In particular, in these problem sets students will be asked to suggest a retrosynthesis and a synthesis for a given target molecule.
The items that will be assessed are: the synthetic strategy suggested, the correction of the reaction conditions and the correction of the structure of all compounds.
The mark obtained for each group member will be modulated according to their participation in this group activity.
40 No
Exam Analysis and discussion of exercises related to the topics of the course 60

Qualificació

Grading of the students that decide to follow a continous assessment:
Exercises to be solved in class or at home: 40%
Exam: 60%

The exam is the only activity that can be retaken. Students that want to improve their marks must submit a request to the professor in advance. Performing again the exam means that they renounce to the mark previously obtained.

Students must get 5 points in order to pass the subject. However, they must get a minimum mark of 4 out of 10 in the exam in order that the marks obtained in the activities that can not be retaken are considered.

(Art. 21.1(UdG). The fraudulent completion of any of the exercises required in the evaluation of a subject (unauthorized use of information; use of false information; use of unauthorized devices; impersonation; total or partial plagiarism; purchase and sale of tests, practices and assignments; etc.) will lead to the failure to pass the subject, regardless of the disciplinary process that may be followed against the offending student.)

Criteris específics de la nota «No Presentat»:
The subject is going to be considered as "Not Presented" only if the student has not carried out any grading activity.

Avaluació única:
According to the UdG regulations, students who decide to take the single assessment must request it within the established deadlines. Upon acceptance, they waive the continuous assessment.

Grading of the students that request the single assessment:
Exam 100%

The exam and the resit exam, if necessary, will be the same as the ones for the continuous assessment students and will be held on the same date.

This exam will assess the achievement of the topics in the course.

Students must get 5 points in the exam in order to pass the subject. This exam can be retaken. Students with a grade above 5 can improve their marks but they must submit a request to the professor in advance. Performing again the exam means that they renounce to the mark previously obtained.

(Art. 21.1(UdG). The fraudulent completion of any of the exercises required in the evaluation of a subject will lead to the failure to pass the subject, regardless of the disciplinary process that may be followed against the offending student.)

Requisits mínims per aprovar:
Continuous assessment:
Students must get 5 points in order to pass the subject. However, they must get a minimum mark of 4 out of 10 in the exam in order that the marks obtained in the activities that can not be retaken are considered.

Single assessment:
Students must get 5 points in the exam in order to pass the subject.

Tutoria

During the course, students will be encouraged to ask for tutorials with the professor to clarify aspects related to the contents of the subject. These tutorials will be performed in-person or online depending on the way is more convenient for the student.

Comunicació i interacció amb l'estudiantat

The communication and interaction with students will be via Moodle, email or the videoconferencing platform designated by the UdG.

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