1. CC01. Introduction.
What is combinatorial chemistry? Nature and combinatorics. Journals and books in combinatorial chemistry. Terms used in combinatorial chemistry. The drug discovery process and combinatorial chemistry. Historical landmarks. Library nomenclature and representation of combinatorial libraries. Synthetic strategies in combinatorial and parallel synthesis. From peptide to nonpeptide. Automation: from milligram to microgram?
2. CC02. Solid phase library synthesis (I).
Solid phase chemistry: an overview. Combinatorial synthetic methods; Libraries on resin beads: The mixed reagent method of the synthesis of combinatorial libraries; Mix and split library synthesis; Peptide library deconvolution; Encoded combinatorial peptide synthesis.
3. CC03. Solid phase library synthesis (II).
Parallel synthetic methods: Libraries on pins, in tea-bags, on laminar solid phases.
Instrumentation for automated solid phase synthesis
4. CC04. Combinatorial and parallel synthesis of small molecules (I). (1) Introduction. (2) Solution-phase parallel synthesis (SPPS): Introduction, comparison with solid-phase synthesis, reaction applied to solution phase combinatorial chemistry, purification principles in solution-phase synthesis, microwave-assisted combinatorial chemistry.
5. CC05. Combinatorial and parallel synthesis of small molecules (II). (3) Liquid-phase parallel synthesis: Introduction, polyethylene glycol (PEG), dendrimer-supported combinatorial chemistry. (4) Solid-phase organic synthesis (SPOS): Introduction, linker systems (safety catch, traceless, cyclisation assisted cleavage, diversity linkers, volatilizable linker).
6. CC06. Combinatorial and parallel synthesis of small molecules (III). Recent examples of parallel synthesis.
7. CC07. Characterization and analysis of chemical libraries (I). (1) Introduction. Positional encoding - spatial arrangement. Split-and-mix synthesis: one-bead-one-compound (OBOC) libraries. Structural characterization by direct methods. Structural characterization by indirect methods: Iterative deconvolution, encoding.
(2) DNA-based encoding techniques. Libraries of DNA displaying one covalently linked chemical entity. Phage display libraries. DNA-encoded self-assembling chemical (ESAC) libraries. DNA-templated organic synthesis as a tool for library construction. PNA-encoded libraries.
8. CC08. Characterization and analysis of chemical libraries (II). Peptide encoding. Edman sequencing. Peptide-encoded peptide libraries. Topologically segregated bifunctional beads. “Ladder” scanning strategies.
9. CC09. Characterization and analysis of chemical libraries (III). (1) Molecular tags. Binary encoding strategy. Haloaromatic tags. Secondary amine tags. Trityl tags. F-Encoded libraries. (2) Isotope encoding. General strategy. Analytical constructs for combinatorial chemistry. (3) Noninvasive encoding. Radiofrequency encoding.
Laser optical encoding.
La nota final (sobre 10) es calcularà a partir de la mitjana ponderada de la nota obtinguda en cadascuna de les activitats avaluables:
Comentari de textos 43%
Elaboració de treballs 33%
Exposició d'un article científic 24%
Per aprobar l'assignatura cal obtenir un miním de 5/10
Criteris específics de la nota «No Presentat»:
Només es qualificarà l'assignatura com a "No presentat" quan no s'hagi realitzat cap activitat d'avaluació.