J Castro; A Benito; M Vilanova; M Ribó; G Tornillo; MJ Smalley "A nuclear-directed human pancreatic ribonuclease variant is cytotoxic for breast cancer cells cultured in 3D and kills cancer stem cells." Esmo Open 3 (2018): 190-. S. Ruíz-Martínez; J. Castro; M. Vilanova; M. Bruix; M. Ribó; V. D. Laurents; A. Benito "Antitumor Viral protein variant selectively cytotoxic for cancer cells when exogenously added." Febs Journal 282 (2015): 244-. Vilanova, M., Castro, J., Tubert, P., Ribo, M., Benito, A. "Ribonucleases directed to the nucleus as a novel proapoptotic anticancer strategy." New Biotechnology 25 (2009): S8-S9. Rodríguez, M.; Benito, A.; Tubert, P.; Castro, J.; Ribó, M.; Beaumelle, B.; Vilanova, M. "Characterization of a bipartite-equivalent nuclear localization signal of a cytotoxic ribonuclease variant." Febs Journal 273 (2006): 290-290.
Castro, J.; Bravo, M.; Albertí, M.; Marsal, A.; Alonso-De Gennaro, M.J.; Martínez-Ferraté, O.; Claver, C.; Van Leeuwen, P. W. N. M.; Romero, I.; Benito, A.; Vilanova, M. "Dinuclear iron complexes of iminopyridine based ligands as selective cytotoxins for tumor cells and inhibitors of cancer cell migration." Pharmaceutics 14 (2022): 2801-. Jessica Castro; Giusy Tornillo; Gerardo Ceada; Beatriz Ramos-Neble; Marlon Bravo; Marc Ribó; María Vilanova; Matthew J. Smalley; and Antoni Benito "A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells." Cancers 13 (2021): 4350-. Glòria García-Galindo; Jessica Castro; Jesús Matés; Marlon Bravo; Marc Ribó; Maria Vilanova; Antoni Benito "The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27KIP1." Molecules 26 (2021): 1319-. David Roura Padrosa; Jessica Castro; Alejandro Romero-Casañas; Marc Ribó; Maria Vilanova; Antoni Benito "Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases." Molecules 23 (2018): 3273-. Jessica Castro; Ester Manrique; Marlon Bravo; Maria Vilanova; Antoni Benito; Xavier Fontrodona; Montserrat Rodríguez; Isabel Romero "A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties." Journal of Inorganic Biochemistry 182 (2018): 124-132. A.Vert; J.Castro; M.Ribó; M.Vilanova; A. Benito "Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance." OncoTargets and Therapy 2018 (2018): 221-237. Santiago Ruiz-Martínez; Jessica Castro; Maria Vilanova; Marta Bruix; Douglas V. Laurents; Marc Ribó; Antoni Benito "A Truncated Apoptin Protein Variant Selectively Kills Cancer Cells." Investigational New Drugs 35 (2017): 260-268. Ruiz-Martínez, S.; Pantoja-Uceda, D.; Castro, J.; Vilanova, M.; Ribó, M.; Bruix, M.; Benito, A.; Laurents, V.D. "Insights into the mechanism of Apoptin's exquisitely selective anti-tumor action from atomic level characterization of its conformation and dynamics." Archives of Biochemistry and Biophysics 614 (2017): 53-64. Vert Company, Anna; Castro Gallegos, Jessica; Ribó i Panosa, Marc; Benito i Mundet, Antoni; Vilanova i Brugués, Maria "Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of onconase." Oncotarget (2016): -. Vert Company, Anna; Castro Gallegos, Jessica; Ribó i Panosa, Marc; Benito i Mundet, Antoni; Vilanova i Brugués, Maria "A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells." Oncotarget 7 (2016): 18309-18324. Vert, A.; Castro, J.; Ruiz-Martínez, S.; Tubert, P., Escribano, D.; Ribó, M.; Vilanova, M.; and Benito, A. "Generation of New Cytotoxic Human Ribonuclease Variants Directed to the Nucleus." Molecular Pharmaceutics 9 (2012): 2894-2902. Castro, Jessica; Ribó, Marc; Puig, Teresa, Colomer, Ramon, Vilanova, Maria & Benito, Antoni "A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines." Investigational New Drugs 30 (2012): 880-888. Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova and Antoni Benito "A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation." BMC Cancer 11 (2011): 9-. Torrent, G.; Benito, A.; Castro, J.; Ribó, M.; Vilanova, M. "Contribution of the C30/C75 disulfide bond to the biological properties of onconase." Biological Chemistry Hoppe-Seyler 389 (2008): 1127-1136. Rodríguez, M.; Benito, A.; Tubert, P.; Castro, J.; Ribó, M.; Beaumelle, B.; Vilanova, M. "A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule." Journal of Molecular Biology 360 (2006): 548-557.
Castro J; Ribo M; Vilanova M, Benito A "Strengths and challenges of secretory ribonucleases as antitumor agents." Pharmaceutics 13 (2021): 1-17. Castro J; Ribo M; Benito A; Vilanova M "Apoptin, a Versatile Protein with Selective Antitumor Activity." Current Medicinal Chemistry (2018): -. Castro J; Ribó M; Benito A; Vilanova M "MiniReview: Nucleus-targeted ribonucleases as antitumor drugs." Current Medicinal Chemistry 20 (2013): 1225-1231.