Dra.  JESSICA CASTRO GALLEGOS

Plana personal

Departament:
BIOLOGIA
Àrea de coneixement:
BIOQUÍMICA I BIOLOGIA MOLECULAR
Grup de recerca:
Enginyeria de Proteïnes

Currículum abreujat

Llicenciada en Biologia (2004) i doctora per la Universitat de Girona (2010). Actualment és professora lectora de l’àrea de Bioquímica i Biologia Molecular de la UdG i està vinculada al grup de recerca d’Enginyeria de Proteïnes de la mateixa universitat. Durant l’any 2016 va realitzar una estada de recerca al European Cancer Stem Cell Research Institute de la Universitat de Cardiff (UK). La seva recerca es basa principalment en l’estudi del mecanisme de citotoxicitat de ribonucleases i en el disseny de noves ribonucleases amb activitat antitumoral.

 

Publicacions de recerca:

  • Insights into the mechanism of Apoptin's exquisitely selective anti-tumor action from atomic level characterization of its conformation and dynamics. Archives of Biochemistry and Biophysics (2017) 
  • A Truncated Apoptin Protein Variant Selectively Kills Cancer Cells. Investigational New Drugs (2017)
  • Approaches to Endow Ribonucleases with Antitumor Activity: Lessons Learned from the Native Cytotoxic Ribonucleases. Anti-cancer Drugs - Nature, Synthesis and Cell (2016)
  • Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of onconase. Oncotarget (2016)
  • A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells. Oncotarget (2016)
  • Nucleus-targeted ribonucleases as antitumor drugs. Current Medicinal Chemistry (2013)
  • A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines. Investigational New Drugs (2012)
  • Generation of New Cytotoxic Human Ribonuclease Variants Directed to the Nucleus. Molecular Pharmaceutics (2012)
  • A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. BMC Cancer (2011)
  • Contribution of the C30/C75 disulfide bond to the biological properties of onconase. Biological Chemistry Hoppe-Seyler (2008)
  • A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule. Journal of Molecular Biology (2006)