Formació acadèmica: Professora Agregada (Bioquímica i Biologia Molecular) Doctora en Biomedicina per la UPF (2008) Llicenciada en Biologia per la UB (2005) Llicenciada en Bioquímica per la UB (2001) Línies de recerca: Estudi de la glicosilació alterada en pròteïnes sèriques per a la cerca de nous biomarcados tumorals (tècniques glicoproteòmiques). Estudi de l'expressió de glicosiltransferases responsables de la biosíntesi d'antigens glucidics associats al tumor i la seva implicació en el fenotip metastàsic. Publicacions de recerca: Greville G, Llop E, Howard J, Madden SF, Perry AS, Peracaula R, Rudd PM, McCann A, Saldova R. 5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells. Clin Epigenetics 13(1):34. 2021. Guerrero PE, Durán A, Ortiz-Duran R, Castro E, Garcia-Velasco A, Llop E, Peracaula R. Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl Lewis X (sLex) in pancreatic adenocarcinoma. Journal of Proteomics, 231, 104004. 2021. Benito Mundet, H.; Llop Escorihuela, E.; Verdaguer Planas, M.; Comas Matas, J.; Lleonart Sitjar, A.; Orts Alis, M.; Amadó Dodony, A. & Rostan Sánchez, C. MULTIDIMENSIONAL RESEARCH ON UNIVERSITY ENGAGEMENT USING A MIXED METHOD APPROACH. Educación XX1. 2021. Guerrero PE, Miró L, Wong BS, Massaguer A, Martínez-Bosch N, Llorens R, Navarro P, Konstantopoulos K, Llop E, Peracaula R. Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion. Int J Mol sci. 21(17):6239. 2020. Gratacós-Mulleras A, Duran A, Asadi Shehni A, Ferrer-Baballé M, Ramírez M, Comet J, de Llorens R, Saldova R, Llop E, Peracaula R. Characterisation of the main PSA glycoforms in aggressive prostate cancer. Scientific Reports, 10:18974. 2020. Greville G, Llop E, Huang C, Creagh-Flynn J, Pfister S, O'Flaherty R, Madden SF, Peracaula R, Rudd PM, McCann A, Saldova R. Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro. Front Oncol. 10:1218. 2020. Llop E, E Guerrero P, Duran A, Barrabés S, Massaguer A, José Ferri M, Albiol-Quer M, de Llorens R, Peracaula R. Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma. World J Gastroenterol. 24(24), 2537-2554. 2018. Balmaña M, Duran A, Gomes C, Llop E, López-Martos R, Ortiz MR, Barrabés S, Reis CA, Peracaula R. Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues. Int. J. Biol Macromol. 112:33-45. 2018. Barrabés, S, Llop, E, Ferrer-Batallé, M, Ramírez, M, Aleixandre, R.N, Perry, A.S, de Llorens, R, Peracaula, R. Anlysis of urinary PSA glycosylation is not indicative of high-risk prostate cancer. Clinica Chimica Acta 470, 97-102. 2017. Ferrer-Batallé M, * Llop E, Ramírez M, Aleixandre RN, Saez M, Comet J, de Llorens R, Peracaula R. Comparative Study of Blood-Based Biomarkers, α2,3-Sialic Acid PSA and PHI, for High-Risk Prostate Cancer Detection. Int J Mol Sci. 18(4). 2017. Barrabés S, Farina-Gomez N, Llop E, Puerta A, Diez-Masa JC, Perry A, de Llorens R, de Frutos M, Peracaula R.Comparative analysis of prostate specific antigen (PSA) by two-dimensional gel electrophoresis and capillary electrophoresis. Electrophoresis. 2017. Llop E, Ferrer-Batallé M, Barrabés S, Guerrero P.E, Ramírez M, Saldova R., Rudd P.M., Aleixandre R.N, Comet J, de Llorens R, Peracaula R. Improvement of Prostate Cancer Diagnosis by Detecting PSA Glycosylation-Specific Changes. Theranostics. 6 (8), 1190-1204. 2016. Balmaña M, Giménez E, Puerta A, Llop E, Figueras J., Fort E, Sanz-Nebot V, de Bolós C, Rizzi A, Barrabés S, de Frutos M, Peracaula R. Increased α1-3 fucosylation of α-1-acid glycoprotein (AGP) in pancreatic cancer. Journal of Proteomics, 132; 144-154. 2016. Balmaña M, Sarrats A, Llop E, Barrabés S, Saldova R, Ferri MJ, Figueras J, Fort E, de Llorens R, Rudd PM, Peracaula R. Identification of potential pancreatic cancer sèrum markers: Increased sialyl-Lewis X on ceruloplasmin. Clin Chim Acta. 442: 56-62. 2015. Bassagañas S, Allende H, Cobler L, Ortiz M.R, Llop E, de Bolós C, Peracaula R. Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines. Cytokine, 75, (1); 197-206. 2015. Pérez-Garay M, Arteta B, Llop E, Cobler L, Pagès L, Ortiz R, Ferri MJ, de Bolós C, Figueras J, de Llorens R, Vidal-Vanaclocha F, Peracaula R. α2,3-sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues. The International Journal of Biochemistry & Cell Biology, 45(8): 1748-1757. 2013. Gutiérrez-Gallego R, Llop E, Bosch J, Segura J. Surface Plasmon Resonance in doping analysis. Analytical and Bioanalytical Chemistry, 401(2), 389-403. 2011. Mallorquí J, Llop E, de Bolós C, Gutiérrez-Gallego R, Segura J, Pascual JA. Erythropoietin purification in human plasma samples using an immunoaffinity well plate. Journal Chromatography B, 878(23), 2117-22. 2010. Martínez-Martínez I, Ordóñez A, Navarro-Fernández J, Pérez-Lara A, Gutiérrez-Gallego R, Giraldo R, Martínez C, Llop E, Vicente V, Corral J. Antithrombin Murcia (K241E) causing antithrombin deficiency: a role for altered glycosylation. Haematologica, 95(8), 1358-65. 2010. Izquierdo-Rico MJ, Jiménez-Movilla M, Llop E, Pérez-Oliva AB, Ballesta J, Gutiérrez-Gallego R, Jiménez-Cervantes C, Avilés M. Hamster Zona Pellucida Is Formed by Four Glycoproteins: ZP1, ZP2, ZP3, and ZP4. J Proteome Research, 8(2), 926-41. 2009. Llop E, Gutiérrez-Gallego R, Segura J, Mallorquí J, Pascual JA. Structural analysis of the glycosylation of gene-activated erythropoietin (epoetin delta, Dynepo). Anal Biochem. 383(2), 243-54. 2008. Ramírez-Llanelis R, Llop E, Ventura R, Segura J, Gutiérrez-Gallego R. Can glycans unveil the origin of glycoprotein hormones? – human chorionic gonadotrophin as an example. J.Mass Spectrometry, 43(7), 936-48. 2008. Llop E, Gutiérrez-Gallego R, Belalcazar V, Gerwig GJ, Kamerling JP, Segura J, Pascual JA. Evaluation of protein N-glycosylation in 2-DE: Erythropoietin as a study case. Proteomics, 7(23), 4278-91. 2007. Belalcazar V, Gutiérrez-Gallego R, Llop E, Segura J, Pascual JA. Assessing the instability of the isoelectric focusing patterns of erythropoietin in urine. Electrophoresis, 27(22), 4387-95. 2006. Pascual JA, Belalcazar V, de Bolós C, Gutiérrez-Gallego R, Llop E, Segura J. Recombinant erythropoietin and analogues: a challenge for doping control. Therapeutic Drug Monitoring, 26(2), 175-79. 2004.