Estudia

• CB01- Identificar problemes, buscar solucions originals i aplicar-les en un context d'investigació o professional
• CB02- Contribuir al teixit europeu d'investigació i desenvolupament amb una visió àmplia i multidisciplinària dins dels camps biològic, biotecnològic, bioquímic, químic i biomèdic
• CB04- Comunicar de forma clara i concisa els seus coneixements, les seves conclusions i les implicacions ètiques i socials del seu camp de treball a públics especialitzats i no especialitzats ( divulgació científica)
• CB05- Actualitzar i prosseguir els seus estudis de forma auto-dirigida i autònoma, recollint i seleccionant la informació necessària que permeti una investigació original i que aporti nous coneixements
• CE04- Identificar i analitzar els mecanismes moleculars bàsics que operen en els éssers vius, particularment l'home, així com les seves aplicacions en diferents camps d'investigació
• CE08- Valorar la utilitat de tècniques de modificació genètica d'organismes per a estudis i tractament de patologies humanes, la millora de processos i productes biotecnològics

1. How gene expression regulation takes place in eukaryotes. Chromatin organization.Histones modification: acetylation, phosphorylation, ubiquitination and sumoylation. Chromatin remodeling complexes. DNA methylation. Loops and chromosome territories.

2. How gene expression regulation takes place in eukaryotes and its comparison with the same process in prokaryotes. DNA sequences involved in transcription: promoters, enhancers, silencers (cis elements). Trans-elements: basal transcription factors, transactivators, coactivators, HMG proteins. Gene expression regulation and signal transduction relationship.

3. Gene expression regulation at post/co-transcriptional level: mechanisms involved. Intron removal. Spliceosome assembly. Alternative splicing: types and functions. How the splicing is regulated?

4. Gene silencing: DICER and RISC complexes, Drosha and its function. Proteins involved in this process. Biogenesis of siRNAs and miRNAs: differences. How siRNAs and miRNAs silence gene expression. Gene silencing and chromatin remodeling relationship.

5. Nucleus-cytoplasm transport of proteins and RNAs: regulatory processes of gene expression. RNAs half-life and their degradation.

6. Regulation of gene expression at post-transcriptional level. Protein targeting. Protein post-translational modifications and their functions.

• Alberts, Bruce (2022). Molecular biology of the cell (Seventh edition, international student edition). New York: W. W. Norton & Company. Catàleg
• Nelson, David L. (2021). Lehninger principles of Biochemistry (Eight edition). New York: Macmillan Learning. Catàleg
• Allis, C. David (cop. 2007 ). Epigenetics . Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press. Catàleg
• Hannon, Gregory J. (cop. 2003 ). RNAI : a guide to gene silencing . Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory.
• Watson, James D. (cop. 2007 ). Recombinant DNA : genes and genomes, a short course (3th ed.). New York: W. H. Freema and Co. Catàleg
• Watson, James D. (2008 ). Molecular biology of the gene (6th ed.). New York: Cold Spring Harbor Laboratory Press [etc.]. Catàleg
• Watson, James D. (2005 ). Biología molecular del gen (5ª ed.). Madrid [etc.]: Médica Panamericana. Catàleg
• Lodish, Harvey F. (cop. 2000 ). Molecular cell biology (4th ed.). New York: W.H. Freeman. Catàleg
• Varki, Ajit (2008 ). The Essentials of glycobiology (2a ed.). Cold Spring Harbor: Cold Spring Harbor Laboratory Press. Catàleg
• Ishigami, Tomoaki (2021). Ubiquitination in Health and Diseases. Basel: Basel, Switzerland: MDPI - Multidisciplinary Digital Publishing Institute. Recuperat , a https://omnia.udg.edu/permalink/34CSUC_UDG/2mi7is/cdi_oapen_doabooks_76311
• Huang, Suming (2016 - 2016). Epigenetic gene expression and regulation (1st ed.). Amsterdam, [Netherlands: Academic Press Catàleg
• Fumiaki Uchiumi (2018). Gene expression and regulation in mammalian cells : transcription toward the establishment of novel therapeutics. Place of publication not identified: IntechOpen Catàleg

Activitats d'avaluació:

The final grade for the oral presentation may differ among group members depending on their individual contributions during the discussion session.

The grade of the individual final exam will be the sum of punctuation of each one of the exercises proposed. Their value will be indicated in each exercise. To pass the course it is mandatory to reach a minimum of 5 over 10 in this exam.

In case that any student does not get a final grade of 5 over 10, only the individual final exam can be repeated.

REMARCK: PENALTY FOR FRAUD OR PLAGIARISM
If fraudulent activity is detected in any of the exercises required for the evaluation of a subject, it will result in failing the corresponding assessment (grade of 0), regardless of the disciplinary process that may be followed against the offending student.

Fraudulent activity includes but it is not restricted to: the use, attempted use, or possession of any system, device, or technology that allows or may allow students to contact external agents or receive unauthorized help, as well as any form of copying exercises required for the assessment of a subject.

Fraudulent behaviour is considered to include the use of information without authorization, use of false information, use of unauthorized devices, impersonation, total or partial plagiarism, purchase and sale of tests, practices and assignments, etc.

USE of AI
Important: If artificial intelligence programs or tools (ChatGPT, Copilot, Gemini, Claude, etc) contributed to the preparation of the slides or oral presentation of the course-related topic must be disclosed specifying its purpose of use as for example, suggesting presentation designs, AI-assisted figure editing, reference manager suggestions, non-generative autocorrect tools.

Authors of the presentation remain fully accountable for accuracy and integrity. All AI-generated content must be critically reviewed and validated by the authors. Fabricated references or unverified AI-generated claims are considered misconduct.
Furthermore, if a broader use of AI that declared by the authors is deteced, the activity will be disqualified and fail the evaluation process.

Criteris específics de la nota «No Presentat»:
It is mandatory the attendance at a minimum of 80% of the lectures to pass the course. A NOT PRESENTED student implies that he/she has not done the final exam and/or that has not presented the written work or has attended less than the 80% of the lectures.

In case of single evaluation, A NOT PRESENTED STUDENT implies that he/she has not done the single final exam and/or has not attended a minimum of 60% of the lectures.

Avaluació única:
Students that can opt for a single evaluation, it would consist in a final exam of the whole content of the course. The exam might content different types of questions: multiple choice, right-wrong questions, reasoned short questions ..., etc. This exam will account for the 100% of the final grade obtained by the student and if failed may be repeated only once.

Students should attend a minimum of 60% of the lectures to get the option for this single evaluation.

Requisits mínims per aprovar:
To pass this course students have to get a grade of 5 or higher either with regular or single evaluation.

Students (single or in reduced groups) can contact teachers by mail and agree a tutorial meeting to solve doubts about the content of the course.

General notifications to the students will be done through the Moodle Platform.

The main way of teachers-students communication will be by mail. Students and teachers can agree an appointment for a meeting (single or in reduced group) at a time and place suitable for both to solve any kind of doubts that cannot be solved by mail.

Important: If artificial intelligence programs or tools (ChatGPT, Copilot, Gemini, Claude, etc) contributed to the preparation of the slides or oral presentation of the course-related topic must be disclosed specifying its purpose of use as for example, suggesting presentation designs, AI-assisted figure editing, reference manager suggestions, non-generative autocorrect tools.

Authors of the presentation remain fully accountable for accuracy and integrity. All AI-generated content must be critically reviewed and validated by the authors. Fabricated references or unverified AI-generated claims are considered misconduct.
Furthermore, if a broader use of AI that declared by the authors is deteced, the activity will be disqualified and fail the evaluation process.


REMARCK: PENALTY FOR FRAUD OR PLAGIARISM
If fraudulent activity is detected in any of the exercises required for the evaluation of a subject, it will result in failing the corresponding assessment (grade of 0), regardless of the disciplinary process that may be followed against the offending student.

Fraudulent activity includes but it is not restricted to: the use, attempted use, or possession of any system, device, or technology that allows or may allow students to contact external agents or receive unauthorized help, as well as any form of copying exercises required for the assessment of a subject.

Fraudulent behaviour is considered to include the use of information without authorization, use of false information, use of unauthorized devices, impersonation, total or partial plagiarism, purchase and sale of tests, practices and assignments, etc.