Dr.  VERGES AIGUAVIVA, MARCEL

Plana personal

Categoria:
PROFESSOR AGREGAT
Departament:
CIÈNCIES MÈDIQUES
Àrea de coneixement:
MEDICINA
Grup de recerca:
Grup de Genètica Cardiovascular
ORCID PRC:
0000-0002-2606-223X

Currículum abreujat

18 February 2016

 

PERSONAL INFORMATION:

 

NAME:           Marcel Vergés

 

BIRTH PLACE and DATE:

Rabós d’Empordà, Province of Girona (Spain)        9 April 1966 

 

PROFESSIONAL INFORMATION:

 

INSTITUTIONAL ADDRESS:

Cardiovascular Genetics Group - Girona Biomedical Research Institute
C/ Doctor Castany, s/n - Edifici Mancomunitat II
Parc Hospitalari Marti i Julià
17190 Salt, Prov. Girona

Tel. +34 872 987087 Ext. 62
E-mail address                        mverges@gencardio.com

 

UdG School of Medicine                  C/ Emili Grahit 77 2nd – 17071 Girona (Spain)

Tel +34 972 419624 (off)

E-mail address                       marcel.verges@udg.edu

 

CURRENT POSITION:

Professor Agregat Interí (Interim Associate Professor)                                                     DATE: Sep 2015

 

TEACHING AND RESEARCH INTERESTS:

-          Cellular biology and biochemistry

-          Molecular mechanisms of protein trafficking

-          Membrane traffic in polarized epithelial cells

-          Traffic of ion channels and associated subunits

 

 

EDUCATION:


INSTITUTION                  DEGREE                            DATE    FIELD OF STUDY

Univ. of Barcelona           B.S.                                   1989               Biology

Univ. of Barcelona            M.S. (Tesina dissertation)  1990           Cell Biology

Univ. of Barcelona             Ph.D.                                1994          Cell Biology

 

 

RESEARCH & TEACHING EXPERIENCE:

 

7/1987             training in microbiological and chemical analysis of food quality – Girona’s Market Laboratory

19881989      collaboration in teaching of laboratory classes – 5th year Biology students; Topic: “Animal Physiology” – Dep. of Biochemistry & Physiology, Univ. of Barcelona School of Biology (Prof. R. Rama)

19881989      collaboration in research – Dep. of Law Medicine & Toxicology, Univ. of Barcelona School of Medicine (Prof. E. Huguet)

19891994      Ph.D. Program – Dep. of Cell Biology, Univ. of Barcelona School of Medicine (Dr. C. Enrich)

10/9112/91    short stay – Lab of Protein Structure, National Institute for Medical Research, London – Dr. W.H. Evans

19911994      teaching of laboratory classes – 1st year Medical students; Topic: Cell Biology – Dep. of Cell Biology, Univ. of Barcelona School of Medicine – Prof. O. Bachs

19951999      Postdoctoral Fellow – Cardiovascular Research Inst. & Dep. of Anatomy, Univ. of California School of Medicine, San Francisco (UCSF) – Profs. R.J. Havel & K.E. Mostov

19992003      Postgraduate Researcher – Dep. of Anatomy, UCSF – Prof. K.E. Mostov

20032004      Assistant Specialist – Dep. of Anatomy, UCSF – Prof. K.E. Mostov

20052009      Head of laboratory – Lab of Epithelial Cell Biology, Príncipe Felipe Research Center (CIPF), Valencia

Since 2010      Senior Researcher – CGC, IdIBGi

Since 2010      Tenure-track Lecturer – Dep. of Medical Sciences, UdG School of Medicine Topics: Biochemistry, Cellular biology & Genetics (1st year medical students; courses 2010/2011 to 2015/2016); Human physiology / the endocrine system (2nd year students; courses 2011/2012 and 2015/2016); Immunology (3rd year students; course 2010/2011); and related areas (1st and 2nd year students; courses 2014/2015, 2015/2016)

Since 2010      Teacher at the Master in Molecular Biology and Biomedicine, UdG Topic: Biological basis of cardiovascular disease (master students; courses 2010/2011 to 2014/2015)

 

 

PARTICIPATION in RESEARCH PROJECTS:

 

TITLE OF THE PROJECT: (information not available)

FUNDING AGENCY: Spanish Advisory Committee for Scientific and Technical Research (CAICYT)                                                                                             REF: PM88 - 0044

PERIOD: 1989 – 1991          AMOUNT AWARDED: (not available)      P.I.: Carlos Enrich

 

TITLE OF THE PROJECT: (information not available)

FUNDING AGENCY: Spanish-British Acciones Integradas, MEC- Spanish Ministry of Education and Science (MEyC)-British Council                                REF: HB -140

PERIOD: 1990 – 1991          AMOUNT AWARDED: (not available)      P.I.: Carlos Enrich

 

TITLE OF THE PROJECT: (information not available)

FUNDING AGENCY: Spanish-British Acciones Integradas, MEC- Spanish Ministry of Education and Science (MEyC)-British Council                                REF: HB -131

PERIOD: 1991 – 1992          AMOUNT AWARDED: (not available)      P.I.: Carlos Enrich

 

TITLE OF THE PROJECT: (information not available)

FUNDING AGENCY: Inter-agency Council on Science and Technology (CICyT) I+D                                                                                                                      REF: SAL90 - 0337

PERIOD: 1991 – 1993          AMOUNT AWARDED: (not available)      P.I.: Carlos Enrich

 

TITLE OF THE PROJECT: (information not available)

FUNDING AGENCY: Inter-agency Council on Science and Technology (CICyT) I+D                                                                                                                      REF: PM92 - 0236

PERIOD: 1993 – 1995          AMOUNT AWARDED: (not available)      P.I.: Carlos Enrich

 

TITLE OF THE PROJECT: Transport of immunoglobulins across epithelial cells

FUNDING AGENCY: National Institutes of Health                                 REF: R01 AI 25144

PERIOD: 1995 – 1999          AMOUNT AWARDED: (not available)      P.I.: Keith Mostov

(It is stated the period of participation.)

 

TITLE OF THE PROJECT: Regulation of transcytosis of polymeric immunoglobulins

FUNDING AGENCY: National Institutes of Health                                 REF: R01 AI 36953

PERIOD: 1999 – 2004          AMOUNT AWARDED: (not available)      P.I.: Keith Mostov

(It is stated the period of participation.)

 

TITLE OF THE PROJECT: Novel method for mucosal delivery of protein drugs

FUNDING AGENCY: National Institutes of Health                                 REF: DK 58061

PERIOD: 2002 – 2004          AMOUNT AWARDED: (not available)      P.I.: Keith Mostov

(It is stated the period of participation.)

 

TITLE OF THE PROJECT: Identificación de dianas del retrómero implicadas en activación y proliferación celular

(Identification of retromer targets involved in cell activation and proliferation)

FUNDING AGENCY: Spanish Ministry of Health                                   REF: PI 04 1113

PERIOD: 2005–2007                        AMOUNT AWARDED: 75,900 €               P.I.: Marcel Vergés

 

TITLE OF THE PROJECT: Alteraciones del tráfico endosomal e implicaciones en enfermedades y procesos de desarrollo

(Alterations of endosomal traffic and implications in disease and developmental processes)

FUNDING AGENCY: Spanish Ministry of Health                                   REF: PI 07 0895

PERIOD: 2008–2009                        AMOUNT AWARDED: 67, 518 €              P.I.: Marcel Vergés

 

TITLE OF THE PROJECT: (complementary funding to project with REF PI 07 0895)

FUNDING AGENCY: Valencian Education Dep.                         REF: ACOMP 2009 076

PERIOD: 2009–2009                        AMOUNT AWARDED: 5,600 €                 P.I.: Marcel Vergés

 

TITLE OF THE PROJECT: Implicación del tráfico intracelular mediado por retromer en diferenciación neuronal.

(Implication of retromer-mediated traffic in neuronal differentiation)

FUNDING AGENCY: Valencian Health Dep.                              REF: AP 089 09

PERIOD: 2009–2009                        AMOUNT AWARDED: 8,000 €                 P.I.: Marcel Vergés

 

TITLE OF THE PROJECT: Intracellular trafficking and localization of the cardiac sodium channel - alterations in heart disease.

(Tráfico intracelular y localización del canal de sodio cardíaco - alteraciones en enfermedades cardíacas.)

FUNDING AGENCY: UdG - Grants for outstanding actions       REF: SING 12/23

PERIOD: 2013–2014                        AMOUNT AWARDED: 1,330 €                 P.I.: Marcel Vergés

 

 

PUBLICATIONS:

 

Enrich, C., Verges, M., and Evans, W.H. (1992) Differential expression of asialoglycoprotein receptor subunits in the endocytic compartment during liver regeneration.  J. Cell. Physiol. 150 (2): 344-352

 

Enrich, C., Verges, M., and Evans, W.H. (1992) Reorganization of the endocytic compartment in regenerating liver.  Exp. Cell Res. 201 (2): 399-407

 

Castro, A., Jaumot, M., Verges, M., Agell, N. and Bachs, O. (1994) Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells.  Biochem. Biophys. Res. Commun. 201 (3): 1072-1078

 

Enrich, C., Verges, M., and Evans, W. H. (1995) Functional identification of three major phosphoproteins in endocytic fractions from rat liver. A comparative in vivo and in vitro study.  Eur. J. Biochem. 231 (3): 802-808

 

Verges, M., Castro, A., Jaumot, M., Bachs, O., and Enrich, C. (1997) Cyclin A is present in the endocytic compartment of rat liver cells and increases during liver regeneration.  Biochem. Biophys. Res. Commun. 230 (1): 49-53

 

Bergeron, N., Kotite, L., Verges, M., Blanche, P., Hamilton, R.L., Krauss, R.M., Bensadoun, A., and Havel, R.J. (1998) Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase.  Proc. Natl. Acad. Sci. USA. 95 (26): 15647-15652

 

Verges, M., Havel, R.J., and Mostov, K.E. (1999) A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default.  Proc. Natl. Acad. Sci. USA. 96 (18): 10146-10151

 

Luton, F., Verges, M., Vaerman, J.P., Sudol, M., and Mostov, K.E. (1999) The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo.  Mol. Cell 4 (4): 627-632  (The two first authors contributed equally to this work)

 

Mostov, K.E., Verges, M., and Altschuler, Y. (2000) Membrane traffic in polarized epithelial cells.  Curr. Opin. Cell Biol. 12 (4): 483-490 (Review)

 

Verges, M., Bensadoun, A., Herz, J., Belcher, J.D., and Havel, R.J. (2004) Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein.  J. Biol. Chem. 279 (10): 9030-9036

 

Verges, M., Luton, F., Gruber, C., Tiemann, F., Reinders, L.G., Huang, L., Burlingame A.L., Haft, C.R., and Mostov, K.E. (2004) The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.  Nat. Cell Biol. 6 (8): 763-769

 

Mostov, K., Brakeman, P., Datta, A., Gassama, A., Katz, L., Kim, M., Leroy, P., Levin, M., Liu, K., Martin, F., O'Brien, L.E., Verges, M., Su, T., Tang, K., Tanimizu, N., Yamaji, T., and Yu, W. (2005) The Formation of multicellular epithelial structures.  Novartis Found. Symp. 269: 193-200; discussion 200-205, 223-230 (Book Chapter)

 

Verges, M., Sebastian, I., and Mostov, K.E. (2007) Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor.  Exp. Cell Res. 313 (4): 707-718  (corresponding author: M. Vergés)

 

Verges, M. (2007) Retromer and sorting nexins in development.  Front. Biosci. 12: 3825-3851 (Review)

 

Verges, M. (2008) Retromer: Multipurpose Sorting and Specialization in Polarized Transport.  Int. Rev. Cell Mol. Biol. 271 (4): 153-198 (Review / Book Chapter)

 

Fuster, J.J., González, J.M., Edo, M.D., Viana, R., Boya, P., Cervera, J., Verges, M., Rivera, J., and Andrés, V. (2010) Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6.  FASEB J. 24 (8): 2998-3009

 

Su, T., Bryant, D.M., Luton, F., Verges, M., Ulrich, S.M., Hansen, K.C., Datta, A., Eastburn, D.J., Burlingame, A.L., Shokat, K.M., and Mostov, K.E. (2010) A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptorNat. Cell Biol. 12 (12): 1143-1153

 

Cuartero, Y., Mellado, M., Capell, A., Álvarez-Dolado, M., and Verges, M. (2012) Retromer Regulates Postendocytic Sorting of β-Secretase in Polarized Madin–Darby Canine Kidney Cells.  Traffic 13 (10): 1393–1410

 

Riuró, H., Beltran-Alvarez, P., Tarradas, A., Selga, E., Campuzano, O., Verges, M., Pagans, S., Iglesias, A., Brugada, J., Brugada, P., Vázquez, F.M., Pérez, G.J., Scornik, F.S., and Brugada, R. (2013) A missense mutation in the sodium channel β2 subunit reveals SCN2b as a new candidate gene for Brugada syndrome.  Hum Mutat. 34 (7): 961-966

 

 

INTERNATIONAL MEETINGS – PRESENTATIONS:

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: Asialoglycoprotein receptor modulation in rat liver endocytic compartment.

TYPE OF PARTICIPATION: Poster

CONGRESS: 3rd EUROPEAN CONGRESS OF CELL BIOLOGY

PUBLICATION: CELL BIOLOGY INTERNATIONAL REPORTS 14 (60), p 213

PLACE: Firenze, ITALY                                                                             September 2-7 1990

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: A study of Calmodulin-binding proteins in the endocytic compartment of rat liver.

TYPE OF PARTICIPATION: Poster

CONGRESS: II EUROPEAN WORKSHOP ON ENDOCYTOSIS

PUBLICATION: CELL BIOLOGY INTERNATIONAL REPORTS, p 78

PLACE: Paris, FRANCE                                                                                 October 1-5 1990

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: Endocytosis during hepatic regeneration. (Translated)

TYPE OF PARTICIPATION: Oral Communication (C. Enrich)

CONGRESS: IV SIMPOSIUM HISPANOPARLANTE DE HEPATOLOGIA

PUBLICATION: RESUMENES DEL IV SIMPOSIUM HISPANOPARLANTE DE HEPATOLOGIA, p.26

PLACE: Barcelona, SPAIN                                                                             October 8-9 1990

 

AUTHORS: Vergés, M., Pujades, C., Evans, W.H., and Enrich, C.

TITLE: Tau proteins in rat liver endosomes.

TYPE OF PARTICIPATION: Oral Communication (C. Enrich)

CONGRESS: INTERNATIONAL FALK SYMPOSIUM ON HEPATIC ENDOCYTOSIS

PUBLICATION: Calmodulin-binding proteins in rat liver endosomes and identification of tau proteins in the endocytic compartment.  In: HEPATIC ENDOCYTOSIS OF LIPIDS AND PROTEINS, ed. by E. Windler and H. Greten, pp. 24-30.  W. Zuckschwerdt Verlag München

PLACE: Hamburg, GERMANY                                                                       June 12-14 1991

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: Tau proteins in rat liver endosomes.

TYPE OF PARTICIPATION: Poster

CONGRESS: JOURNAL OF CELL BIOLOGY

PUBLICATION: ABSTRACTS OF THE JOURNAL OF CELL BIOLOGY 115 (3,2), p. 76

PLACE: Boston, MA, USA                                                                        December 8-12 1991

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: Identification of hepatic endocytic proteins potentially involved in membrane traffic.

TYPE OF PARTICIPATION: Poster

CONGRESS: MOLECULAR MECHANISMS OF MEMBRANE TRAFFIC

PUBLICATION: Identification of hepatic endocytic proteins potentially involved in membrane traffic. (12c)  In: MOLECULAR MECHANISMS OF MEMBRANE TRAFFIC, ed. by J. Morré et al., pp. 311-312.  Springer-Verlag, Heidelberg/New York

PLACE: Airlie, VA, USA                                                                                    May 9-13 1992

 

AUTHORS: Vergés, M., Enrich, C., and Evans, W.H.

TITLE: Biochemical properties and expression of tau proteins in the endocytic compartment during liver regeneration.

TYPE OF PARTICIPATION: Poster

CONGRESS: MOLECULAR MECHANISMS OF MEMBRANE TRAFFIC

PUBLICATION: Identification of hepatic endocytic proteins potentially involved in membrane traffic. (35c)  In: MOLECULAR MECHANISMS OF MEMBRANE TRAFFIC, ed. by J. Morré et al., pp. 309-310.  Springer-Verlag, Heidelberg/New York

PLACE: Airlie, VA, USA                                                                                    May 9-13 1992

 

AUTHORS: Vergés, M., Enrich, C., and Evans, W.H.

TITLE: Expression of tau proteins in the endocytic compartment of rat liver during the regeneration.

TYPE OF PARTICIPATION: Oral Communication (M. Vergés) and Poster

CONGRESS: 5th INTERNATIONAL CONGRESS ON CELL BIOLOGY

PUBLICATION: (poster discussion session: PD-6, 1; and poster: P-4.1, 134)

PLACE: Madrid, SPAIN                                                                                    July 26-31 1992

 

AUTHORS: Vergés, M., Castro, A., Jaumot, M., Bachs, O., and Enrich, C.

TITLE: Characterization of a liver endocytic protein biochemically related to tau proteins.

TYPE OF PARTICIPATION: Poster

CONGRESS: MEMBRANE DYNAMICS ON ENDOCYTOSIS

PUBLICATION: none

PLACE: Pisa, ITALY                                                                                          May 8-13 1993

 

AUTHORS: Vergés, M., Castro, A., Bachs, O., and Enrich, C.

TITLE: Identification of cyclin A in rat liver endocytic fractions. Expression during liver regeneration.

TYPE OF PARTICIPATION: Poster

CONGRESS: 4th EUROPEAN CONGRESS OF CELL BIOLOGY

PUBLICATION: CELL BIOLOGY INTERNATIONAL REPORTS 18 (5), p. 475 (Tu-165)

PLACE: Prague, CZECH REPUBLIC                                                        June 26-July 1 1994

 

AUTHORS: Castro, A., Jaumot, M., Vergés, M., Agell, N., Bachs, O., and Enrich, C.

TITLE: Cyclin A is located in rat liver microsomes during liver regeneration.

TYPE OF PARTICIPATION: Poster

CONGRESS: 4th EUROPEAN CONGRESS OF CELL BIOLOGY

PUBLICATION: CELL BIOLOGY INTERNATIONAL REPORTS 18 (5), p. 582 (Th-181)

PLACE: Prague, CZECH REPUBLIC                                                        June 26-July 1 1994

 

AUTHORS: Vergés, M., Castro, A., Bachs, O., and Enrich, C.

TITLE: Identification of cyclin A in rat liver endocytic fractions.

TYPE OF PARTICIPATION: Poster

CONGRESS: AMERICAN SOCIETY FOR CELL BIOLOGY (ASCB) 34th Annual Meeting

PUBLICATION: Abstracts of the MOLECULAR BIOLOGY OF THE CELL 5, p.193a (1125)

PLACE: San Francisco, CA, USA                                                            December 10-14 1994

 

AUTHORS: Enrich, C., Vergés, M., Pol, A., and Ortega, D.

TITLE: Endocytic function during liver regeneration.

TYPE OF PARTICIPATION: Oral Communication (C. Enrich)

CONGRESS: DIFERENCIACION CELULAR

PUBLICATION: JOURNAL OF PHYSIOLOGY - LONDON 493(P): 158S-159S, Cambridge Univ. Press, New York, from PHYSIOLOGY OF PROLIFERATING CELLS

PLACE: Salamanca, SPAIN                                                                                        May 1996

 

AUTHORS: Luton, F., Vergés, M., and Mostov, K.E.

TITLE: Role of p62YES in controlling dimeric IgA transcytosis into mucosal secretions.

TYPE OF PARTICIPATION: Oral Communication (F. Luton)

CONGRESS: ASCB 38th Annual Meeting

PUBLICATION: Abstracts of the MOLECULAR BIOLOGY OF THE CELL 9, p.259a (1499)

PLACE: San Francisco, CA, USA                                                            December 12-16 1998

 

AUTHORS: Vergés, M., Luton, F., Reinders, L.G., Huang, L., Burlingame, A.L., Haft, C.R., and Mostov, K.E.

TITLE: The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.

TYPE OF PARTICIPATION: Oral Communication (M. Vergés)

CONGRESS: ASCB 42nd Annual Meeting

PUBLICATION: Abstracts of the MOLECULAR BIOLOGY OF THE CELL 13, p.421a (2369)

PLACE: San Francisco, CA, USA                                                            December 14-18 2002

 

AUTHORS: Su, T., Luton, F., Verges, M., Ulrich, S.M., Hansen, K., Burlingame, A.L., Shokat, K.M., and Mostov, K.E.

TITLE: The roles of the Src family protein tyrosine kinase c-Yes and epidermal growth factor receptor in transcytosis of polymeric immunoglobulin A mediated by the polymeric immunoglobulin receptor.

TYPE OF PARTICIPATION: Poster

CONGRESS: ASCB 43rd Annual Meeting

PUBLICATION: Abstracts of the MOLECULAR BIOLOGY OF THE CELL 14, p. 75a (413)

PLACE: San Francisco, CA, USA                                                            December 13-17 2003

 

AUTHORS: Mostov, K.E., et al. (17 authors in alphabetic order, incl. Verges, M.)

TITLE: The Formation of multicellular epithelial structures.

TYPE OF PARTICIPATION: Oral Communication (K.E. Mostov)

CONGRESS: Novartis Foundation Symposium: SIGNALLING NETWORKS IN CELL SHAPE AND MOTILITY 269, p. 193-200 (discussion 200-205, 223-230), ed. by Wiley, Chichester

PLACE: Singapore, REPUBLIC OF SINGAPORE                    August 30-September 2 2004

 

AUTHORS: Su, T., Luton, F., Verges, M., Ulrich, S.M., Hansen, K., Burlingame, A.L., Shokat, K.M., and Mostov, K.E.

TITLE: Regulation of IgA-pIgR Transcytosis by EGFR-MEK-ERK Signaling Pathway in Epithelial Cells.

TYPE OF PARTICIPATION: Poster

CONGRESS: ASCB 45th Annual Meeting

PUBLICATION: Abstracts of the MOLECULAR BIOLOGY OF THE CELL 16, p.320a (1178)

PLACE: San Francisco, CA, USA                                                            December 10-14 2005

 

AUTHORS: Mellado, M., Cuartero, Y., Piquer, M., Capell, A., Kremmer, E., Alvarez-Dolado, M., and Verges, M.

TITLE: Involvement of retromer in traffic of β-site amyloid precursor protein (APP) cleaving enzyme (BACE) and β-APP.

TYPE OF PARTICIPATION: Poster

CONGRESS: EUROPEAN LIFE SCIENTIST ORGANISATION (ELSO) 6th International Congress

PUBLICATION: Proceedings p.202 (425)

PLACE: Dresden, GERMANY                                                                   September 1-4 2007

 

AUTHORS: Cuartero, Y., Mellado, M., Alvarez, B., Capell, A., Alvarez-Dolado, M., and Verges, M.

TITLE: Role of retromer in traffic of β-site amyloid precursor protein (APP) cleaving enzyme (BACE) and β-APP.

TYPE OF PARTICIPATION: Poster

CONGRESS: ELSO 7TH International Congress

PUBLICATION: Proceedings p.184 (345)

PLACE: Nice, FRANCE                                                               August 30-September 2 2008

 

AUTHORS: Cuartero, Y., Mellado, M., Capell, A., Alvarez-Dolado, M., and Verges, M.

TITLE: Role of retromer in traffic of the β-site amyloid precursor protein (APP) cleaving enzyme (BACE) and β-APP.

TYPE OF PARTICIPATION: Poster

CONGRESS: European Science Foundation – European Molecular Biology Organization (ESF – EMBO) Symposium on Cell Polarity and Membrane Traffic

PUBLICATION: Abstracts Book p.29 (Poster 22)

PLACE: Sant Feliu de Guíxols, SPAIN                                                            May 23-28 2009

 

AUTHORS: Mellado, M., Cuartero, Y., Brugada, R., and Verges, M.

TITLE: Subcellular location of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells.

TYPE OF PARTICIPATION: Poster

CONGRESS: Lysosome Related Organelles Conference

PUBLICATION: Abstracts Book p.87

PLACE: Nerja, Málaga, SPAIN                                                                  February 13-16 2014

 

 

NATIONAL / LOCAL MEETINGS – PRESENTATIONS:

 

AUTHORS: Enrich, C., Vergés, M., and Evans, W.H.

TITLE: Regulation of the asyaloglycoproteins receptor expression during hepatic regeneration. (Translated)

TYPE OF PARTICIPATION: Oral Communication (C. Enrich)

CONGRESS: VII JORNADES DE BIOLOGIA MOLECULAR

PUBLICATION: BIOLOGIA MOLECULAR 7: 82-84

PLACE: Cabrera de Mar, Barcelona, SPAIN                                                    May 25-26 1990

 

AUTHORS: Vergés, M., and Enrich, C.

TITLE: Calmodulin-binding proteins in hepatic endosomes. Study during hepatic regeneration. (Translated)

TYPE OF PARTICIPATION: Oral Communication (M. Vergés)

CONGRESS: VIII SEMINARI DE BIOLOGIA DEL DESENVOLUPAMENT

PUBLICATION: BIOLOGIA MOLECULAR 8: 49-58

PLACE: St. Quirze de Safaja, Barcelona, SPAIN                                             June 28-30 1990

 

AUTHORS: Vergés, M., Hostench, J., Pujades, C., and Enrich, C.

TITLE: Tau proteins in rat liver endosomes. (Translated)

TYPE OF PARTICIPATION: Oral Communication (M. Vergés)

CONGRESS: IX SEMINARI DE BIOLOGIA DEL DESENVOLUPAMENT

PUBLICATION: BIOLOGIA DEL DESENVOLUPAMENT 9: 36-47

PLACE: St. Quirze de Safaja, Barcelona, SPAIN                                             June 19-21 1991

 

AUTHORS: Vergés, M., Castro, A., and Enrich, C.

TITLE: Biochemical properties and expression of tau proteins in the endocytic compartment during hepatic regeneration. (Translated)

TYPE OF PARTICIPATION: Oral Communication (M. Vergés)

CONGRESS: X SEMINARI DE BIOLOGIA DEL DESENVOLUPAMENT

PUBLICATION: BIOLOGIA DEL DESENVOLUPAMENT 10: 189-200

PLACE: St. Quirze de Safaja, Barcelona, SPAIN                                             June 18-20 1992

 

AUTHORS: Vergés, M., Luton, F., Reinders, L.G., Huang, L., Burlingame, A.L., and Mostov, K.E.

TITLE: Interaction of the polymeric IgA receptor with vps35 in liver endosomes.

TYPE OF PARTICIPATION: Poster

CONGRESS: BIOMEDICAL SCIENCES GRANLIBAKKEN RETREAT

PUBLICATION: none

PLACE: Lake Tahoe, CA, USA                                                                   November 4-6 2000

 

AUTHORS: Vergés, M., Luton, F., Reinders, L.G., Huang, L., Burlingame, A.L., Haft, C.R., and Mostov, K.E.

TITLE: Association of the mammalian retromer with the polymeric IgA receptor in polarized cells.

TYPE OF PARTICIPATION: Poster

CONGRESS: UCSF CARDIOVASCULAR & PULMONARY RESEARCH GROUP RETREAT

PUBLICATION: none

PLACE: Lake Tahoe, CA, USA                                                               November 12-13 2001

 

AUTHORS: Cárcel-Trullols, J., Cuka N., Verges M., y Knecht E.

TITLE: Study of transport mechanisms by lysosomal enzymes in neuronal ceroid lipofuscinosis.

(Translated)

TYPE OF PARTICIPATION: Poster

CONGRESS: I Reunión Anual del Centro de Investigación Biomédica en Red de Enfermedades Raras – CIBERER group: U721

PUBLICATION: none

PLACE: Barcelona, SPAIN                                                                      November 12-13 2007

 

 

PRESENTATIONS AND SEMINARS as a PhD:

 

-          Identification of endosome proteins in rat liver. Study during the hepatic regeneration – job talk: Dept of Anatomy - School of Medicine, UCSF, CA (1994)

-          Endocitosis durante la regeneración hepática en rata (Endocytosis during the hepatic regeneration in rat) – invited seminar: Dept of Cellular Biology, UdG (1995)

-          The tyrosine kinase p62Yes regulates IgA transcytosis – Seminar at the Signaling Club - School of Medicine, UCSF, CA (2000)

-          Retromer controla la transcitosis del receptor de las inmunoglobulinas poliméricas (Retromer regulates transcytosis of the polymeric immunoglobulin receptor) – 5 job talks: Dep. of Cell Biology, Univ. of Barcelona School of Medicine; Cell and Molecular Biology Unit, Municipal Institute of Medical Research, Barcelona; Scientific Seminars of the Barcelona Science Park; Cell Biology Unit, Severo Ochoa Molecular Biology Center (CBMSO), Madrid; Scientific Seminars of the Fundación Valenciana de Investigaciones Biomédicas, Valencia; Research Center in Neuroscience and Biomedicine, Univ. of Barcelona (2003)

-          Conexión entre transporte de membrana y señalización celular (Link between membrane transport and cell signaling) – Mini-seminars at the CIPF, Valencia (2005)

-          Curriculum Vitae presentation for the Spanish National Research Council (CSIC; job talk): Autonomous Univ. of Barcelona (2005)

-          Sorting intracelular regulado por retromer (Intracellular sorting regulated by retromer) – Scientific Seminars of the Valencia Institute of Biomedicine (2006)

-          Sorting endosomal de proteínas regulado por retromer (Endosomal protein sorting regulated by retromer) – Follow up of Research Project funded by the Ministerio de Sanidad y Consumo, Madrid (2007)

-          Retromer in endosomal sorting – Collaborative Research Center SFB 596, Ludwig-Maximilians-Universität Muenchen, Munich (2007)

-          Retromer-mediated traffic in polarized cells – Faculty Candidate Seminar: Dep. of Experimental and Health Sciences, Pompeu Fabra Univ., Barcelona (2009)

-          Curriculum Vitae presentation for the Spanish National Research Council (CSIC; job talk): CBMSO, Madrid (2009)

-          Tràfic mediat per retromer en cèl·lules polaritzades (Retromer-mediated traffic in polarized cells) – Faculty Candidate Seminar: CGC, IdIBGi – UdG (2009)

-          Presentation of Research & Teaching activity – Faculty Candidate Seminar: UdG (2010): appointed as Professor Lector (Tenure-track Lecturer)

 

 

MANUSCRIPTS IN PREPARATION:

 

-          Mellado, M., Cuartero, Y., Brugada, R., and Verges, M. Subcellular localization of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells.

-          Carcel-Trullols, J., Vidal-Donet, J.M., Aguado C., Verges M., and Knecht E. Alterations in EGF-endocytosis, lysosomal enzyme transport and maturation of cathepsins in Juvenile Neuronal Lipofuscinosis fibroblasts.

 

 

SUPERVISION of RESEARCH ACTIVITIES:

 

-          To set up techniques or procedures with especial relevance to companies:

 

ACTIVITY: Optimization of protein quantitation techniques by Western blotting using the Odyssey Infrared Imaging System

NAME AND POSITION OF THE PERSON SUPERVISED: Dana Avrahami (lab technician)

INSTITUTION: Dep. of Anatomy, UCSF                                      PERIOD: 2000–2002

COMPANY OR LAB IMPLICATED IN THE PROJECT: LI-COR Biosciences, Lincoln, NE – financed partially our salaries and provided funding during the Beta testing of the apparatus

 

ACTIVITY: Identification of non-receptor tyrosine kinase substrates in vivo, expression of the kinases in bacteria and purification maintaining their activity

NAME AND POSITION OF THE PERSON SUPERVISED: Tao Su (postdoctoral fellow)

INSTITUTION: Dep. of Anatomy, UCSF                                      PERIOD: 2000–2002

COMPANY OR LAB IMPLICATED IN THE PROJECT: Kevan Shokat Lab, Dep. of Cellular and Molecular Pharmacology, UCSF – provided the technology for identification of the substrates

 

ACTIVITY: Development of antisense techniques in polarized epithelial cells

NAME AND POSITION OF THE PERSON SUPERVISED: Carmen Gruber (lab technician)

INSTITUTION: Dep. of Anatomy, UCSF                                      PERIOD: 2000–2002

COMPANY OR LAB IMPLICATED IN THE PROJECT: Atugen, AG (currently, Silence Therapeutics, London) – provided reagents and technical expertise (proprietary agreement signed)

 

-          Research training:

 

ACTIVITY: Predoctoral Research Project for identification of retromer targets involved in cell activation and proliferation

NAME AND POSITION OF THE PERSON SUPERVISED: Isabel Sebastian (student)

INSTITUTION: CIPF                                                                                  PERIOD: 2005–2006

 

ACTIVITY: Technician at the Lab of Epithelial Cell Biology

NAME AND POSITION OF THE PERSON SUPERVISED: Maravillas Mellado (technician)

INSTITUTION: CIPF                                                                                  PERIOD: 2005–2009

 

ACTIVITY: Ph.D. Program (Univ. of Valencia) to study “Role of retromer in traffic of β-secretase and the β-amyloid precursor protein in polarized MDCK cells” – Thesis defense on March 1, 2012 graded with "Cum laude"

NAME AND POSITION OF THE PERSON SUPERVISED: Yasmina Cuartero (PhD student)

INSTITUTION: CIPF                                                                                  PERIOD: 2007–2012

 

ACTIVITY: Master’s Program (UdG) to study “Intracellular traffic and localization of Nav1.5 and accessory β subunits” – defense on July 23, 2013

NAME AND POSITION OF THE PERSON SUPERVISED: Sònia Palomeras (student)

INSTITUTION: CGC, IdIBGi – UdG                                            PERIOD: 2013

 

ACTIVITY: Master’s Program (UdG) to study “Regulation of traffic of the voltage-gated sodium channel β2 subunit” – in progress

NAME AND POSITION OF THE PERSON SUPERVISED: Robert Serradesanferm (student)

INSTITUTION: CGC, IdIBGi – UdG                                            PERIOD: 2014

 

ACTIVITY: Master’s Program (UdG) to study “Regulation of traffic of the voltage-gated sodium channel β2 subunit” – in progress

NAME AND POSITION OF THE PERSON SUPERVISED: Leidy V. Cobos (student)

INSTITUTION: CGC, IdIBGi – UdG                                            PERIOD: 2014

 

 

OTHER MERITS related to the RESEARCH ACTIVITY:

 

-          Research Highlights on Verges et al. Nat. Cell Biol. 6 (8): 763-769 – Driving the transcytosis pathway – in Nat. Immunol. 5 (9): 881 (Sep. 2004)

-          Referee for Journal Citation Reports-indexed journals since 2005: Mol. Biol. Cell, The FEBS J., The Biological Bulletin, and Mol. Cell. Biol. (1 manuscript revision for each)

-          Thesis Committee member for the dissertation of Esther Rincón Gila, Dep. of Molecular Biology – School of Sciences, Autonomous Univ. of Madrid / Spanish National Center of Biotechnology (19 June 2009)

-          Collaboration with the National Evaluation and Foresight Agency (ANEP) of the Spanish Ministry of Science and Innovation (MICINN) since 2009: 5 research projects evaluated – Topic: Genetics, Cellular and Molecular Biology (BMC)

-          Collaboration with the Fund for the Scientific and Technological Research (FONCyT) of the National Agency for Scientific and Technological Promotion – Ministry of Science, Technology and Productive Innovation (MINCyT, Argentina) since 2010: 2 research projects evaluated – Topic: Cell and Molecular Biology / Medical Sciences

-          Member in Evaluation Commissions for research stuff at the UdG since 2011: ref. PR-74/11, ref. INV6 2011, i ref. INV65_2013

-          Collaboration with the European Research Council as external Evaluators of for 1 European Research Council (ERC) Advanced Grant projects (1 project evaluated in 2012) – Topic: Cell and Development Biology

 

FELLOWSHIPS & PERSONAL AWARDS after GRADUATION:

 

-          Fellowship for Formation of Research Personnel (FPI) intended for Thesis applicants, by the Spanish Ministry of Education and Science (MEyC): 1991, renewed for 1992, 1993 and 1994. Institution: Dep. of Cell Biology, Univ. of Barcelona School of Medicine

-          Institutional Fellowship for Initiation of Research Projects, by the Interdepartmental Center for Technologic Innovation (CIRIT): 1991. Institution: Dep. of Cell Biology, Univ. of Barcelona School of Medicine

-          Fellowship for FPI intended for postdoctoral stays in a foreign country, by the MEyC: 1995/6, renewed for 1996/7. Institution: Cardiovascular Research Institute and Dep. of Anatomy, UCSF

-          Contract under the Ramón y Cajal Program aimed to incorporate researchers at the R&D system in a Spanish institution, by the Spanish Ministry of Science and Technology (MCyT): 2004 – 2009. Institution: CIPF

 

 

CONTINUING POST-DOCTORAL EDUCATION & EVALUATIONS:

 

-          Science Writing Course (Jan – Mar 1996). Presenter: Mimi Zeiger, M.A. – Cardiovascular Research Institute, UCSF

-          The Art of Lecturing Course (Jan – Mar 1997). Presenters: John Goerke M.D. and Mimi Zeiger, M.A. – Cardiovascular Research Institute, UCSF

-          Favorable report as “Professor Lector” (Tenure-track Lecturer) File # 541/LEC/2003, by the Catalan University Quality Assurance Agency (AQU Catalunya)

-          Positive evaluation as “Profesor Ayudante Doctor” (Doctoral Teaching Assistant), Ref 2003-7315; “Profesor Contratado Doctor” (Tenured Lecturer), Ref 2003-7839; and “Profesor de Universidad Privada” (Private University Teacher), Ref 2003-7840, by the National Agency for Quality Assessment and Accreditation (ANECA)

-          Research project entitled “Identificación de dianas del retrómero” (Identification of retromer targets) selected to participate in the 2nd edition of the Bioemprenda Program (Oct 2004), on advising and training for commercial exploitation of results in research – Vitalia Consulting, Valencia

-          License as a Supervisor of a radioactive facility (29 Nov 2005), issued by the Spanish Consejo de Seguridad Nuclear

-          Positive evaluation by the external Scientific Advisory Board for the CIPF (19 May 2006)

-          Favorable inform of an outstanding scientific career: “Programa de Incentivación para la Incorporación e Intensificación de la Actividad Investigadora” – Program I3 (23 Oct 2008), by the ANEP

-          Problem Based Learning Courses – Basic (17 – 18 Nov 2009), Tutors (1 – 2 Dec 2009), and Evaluation (19 Jan 2010). Presenter: Prof. Luis A. Branda – UdG

-          Favorable report of Research Merits through evaluation by AQU Catalunya – periods 1996-2001 and 2002-2007

-          Favorable report of Triennial teaching period by UdG (October 1 2013)

 

 

KNOWLEDGE of LANGUAGES (F: fair/basic; W: working knowledge, E: fluent or excellent):

 

LANGUAGE            spoken            written                        reading

   English                         E                    E                     E

   Spanish                         E                    E                     E

   Catalan                         E                    E                     E

   French                          F                    F                     W