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Dr.  VERGES AIGUAVIVA, MARCEL

Plana personal

Categoria
PROFESSOR AGREGAT
Departament
CIÈNCIES MÈDIQUES
Àrea de coneixement
MEDICINA
Grup de recerca
Grup de Genètica Cardiovascular
ORCID PRC:
0000-0002-2606-223X

Currículum abreujat

CV date

Nov. 6, 2020

Part A. PERSONAL INFORMATION

First and Family name

Marcel Vergés

 

 

Age

54

Researcher codes

WoS Researcher ID

L-5784-2014

 

SCOPUS Author ID

6603954505

 

Open Researcher and Contributor ID (ORCID)

0000-0002-2606-223X

 

           

A.1. Current position

Name of University/Institution

Univ. of Girona (UdG)

 

Department

Medical Sciences 

 

Address and Country

Emili Grahit 77 – 2nd fl., 17071 – Girona, Spain

 

Phone number

+34606726173

E-mail

marcel.verges@udg.edu

Current position

Associate Professor

From

2015

Key words

cardiac arrhythmias; protein trafficking; voltage-gated sodium channel; NaV1.5; SCN2B

 

             

A.2. Education

PhD

University

Year

Biological Sciences

Univ. of Barcelona (UB)

1994

A.3. JCR articles, h Index, thesis supervised…

Publications and citation report (as of Nov. 6, 2020):

32 publications found in the WoS

27 results in PubMed

Number of articles as first or senior (corresponding) author: 16

Sum of Times Cited (WoS): 868

Avg. citations / year (WoS): 2,2

Avg. citations / article (WoS): 33,4

Num. of publ. in top Quartile (WoS): 20 (at year of publication)

Number of publ. in top Decile (WoS): 9

H-index (WoS): 13

Theses supervised:

. Yasmina Cuartero (CIPF - Univ. of Valencia): Función del retromer en el tráfico de ß-secretasa y de la proteína precursora del péptido ß-amiloide en células polarizadas MDCK - 2012 - Sobresaliente Cum laude - fellowship CIPF PR 01/2007 (2007-2010)

. Eric Cortada (GenCardio, IDIBGI - UdG) – scheduled for dissertation - Trafficking and function of the voltage-gated sodium channel ß2 subunit. - fellowship AGAUR (Generalitat de Catalunya) 2017 FI_B 00071 (2017-2020)

Part B. CV SUMMARY (max. 3500 characters, including spaces)

The topic of my doctoral thesis (Dep. of Cell Biology – UB School of Medicine) focused on dissecting the endocytic pathway in polarized cells using rat liver as a model; my PhD adviser was Prof. C. Enrich (Biochem. Biophys. Res. Commun. 1997).

In 1995, I began a postdoctoral stay at the Univ. of California San Francisco – Cardiovascular Research Inst., under the joint supervision of Prof’s. R. Havel & K. Mostov, the latter, of the Anatomy Dep. With Prof. Havel, I focused on lipoprotein uptake and trafficking in hepatocytes, using rat and knockout mice as model systems (Proc. Natl. Acad. Sci. U.S.A. 1999; J. Biol. Chem. 2004). In 1999, I joined the Mostov lab, focusing on regulation of transcytosis in polarized cells (Mol. Cell 1999). My results contributed to a better understanding of polarized trafficking, demonstrating the role by retromer in mediating polarized protein sorting at the endosome (Nat. Cell Biol. 2004).

In 2004, through a Ramón y Cajal contract, I started up my own lab at the Centro de Investigación Príncipe Felipe (CIPF) in Valencia. There, I continued with my efforts to elucidate the mechanisms by which retromer regulates polarized sorting (Exp. Cell Res. 2007; Front. Biosci. 2007; Int. Rev. Cell Mol. Biol. 2008). In 2006, our lab was positively evaluated by the CIPF’s External Scientific Advisory Committee. In 2008, ANEP issued a favorable report on my research career within the I3 Program, yet my mind was already focused on the new medical studies project that had started at the UdG.

In 2010, I obtained a position as tenure-track Lecturer at the UdG School of Med and, as a senior researcher, I also joined GenCardio (led by Prof. R. Brugada) – Girona Biomedical Research Institute (IDIBGI).

Then, Dr. Yasmina Cuartero (Traffic 2012) defended her thesis, carried out at the CIPF; her results helped to better understand the link of sorting defects by retromer and generation of the ß-amyloid peptide, as cause and aggravating factor of Alzheimer's disease. For a while, I continued interested in analyzing localization of retromer and its function in polarized trafficking (Biol. Cell 2014; Int. Rev. Cell Mol. Biol. 2015).

At GenCardio, I collaborated with Dr. H. Riuró during her thesis. We showed for the first time the association with Brugada syndrome (BrS) of SCN2B, the gene encoding the voltage-gated sodium (NaV) channel ß2 subunit (Hum. Mutat. 2013); BrS patients display cardiac arrhythmia that can lead to sudden death. Subsequently (Biol. Cell 2017), we achieved a better understanding on why ß2 D211G – the BrS-associated mutant – is defective in promoting localization to the cell surface of NaV1.5, the major NaV isoform in the heart. Evidence of my interest on this area of research is my implication in reviewing and commenting on related work (Acta Physiol. 2017; Biomolecules 2019; Acta Physiol. 2020; Acta Physiol. 2020).

During this period, I have obtained the positive assessment by AQU Catalunya for research merits of 3 requested periods (Sexenios), from 1996 to 2013, both included. Also, in 2015, I received accreditation by the AQU to be hired as Associate Prof., and similarly by the ANECA; indeed, last July, and through public examination, I was appointed permanent faculty as Associate Prof. for the UdG at the Medical Sciences Dep. (Area of Medicine).

In recent years, I have supervised 6 master and 5 undergraduate students. Currently, I’m supervising the thesis of Mr. Eric Cortada. In his latest achievement (J. Biol. Chem. 2019), we show the key importance of ß2 N-glycosylation in its trafficking and in promoting NaV1.5 localization to the plasma membrane. Meanwhile, Eric has data on the role of ß2 the cytoplasmic domain, whose modification by palmitoilación appears to increase ß2 affinity for cholesterol-enriched lipid raft domains and regulate the polarized surface localization of ß2 (manuscript under revision in the J. Cell Sci.). The mechanisms analyzed by Eric are fundamental for cardiac function, since possible alterations can affect cell excitability and electrical coupling of the heart.

Regarding Eric’s future, I wish to mention that he has spent a 3-month stay at the lab of Prof. Lori Isom, from the Univ. of Michigan (Ann Arbor, MI), supported by the UdG and the AGAUR. The aim was to study the function of ß2 in cardiomyocytes of SCN2B knockout mice, also using rat neonatal cardiomyocytes and immortalized cell lines. Finally, his Thesis defense is scheduled for the end of the current month, since is beginning next a postdoctoral stay at Cornell University (Ithaca, NY).

Part C. RELEVANT MERITS

C.1. Publications (including books) – in the last 10 years

- Trafficking of Cardiac Ion Channels - Mechanisms and Alterations Leading to Disease 2020; Printed Edition of the Special Issue Published in Biomolecules (Edited by M. Verges), ISBN 978-3-03943-473-2

- Cortada, E. and Verges, M. NaV1.5 in embryonic heart development. Acta Physiol. (Oxf) 2020 Oct; 230 (2): e13542 (Editorial)

- Cortada, E. and Verges, M. Alterations in ubiquitin-mediated degradation of NaV1.5 can cause arrhythmia. Acta Physiol. (Oxf) 2020 Jun; 229 (2): e13459 (Editorial)

- Cortada, E., Brugada, R., and Verges, M. Trafficking and function of the voltage-gated sodium channel ß2 subunit. Biomolecules 2019 Oct 13; 9 (10): E604 (Review)

- Cortada, E., Brugada, R., and Verges, M. (N-glycosylation of the voltage-gated sodium channel ß2 subunit is required for efficient trafficking of NaV1.5/ ß2 to the plasma membrane. J. Biol. Chem. 2019 Nov 1; 294 (44): 16123-16140

- Pagans S., and Vergés M. (2017) A mechanism for NaV1.5 downregulation and sodium current decrease in heart failure. Acta Physiol. (Oxf) 2017 Sep; 221(1): 11-13 (Editorial)

- Dulsat, G.*, Palomeras, S.*, Cortada, E.*, Riuró, H., Brugada, R., and Vergés, M. Trafficking and localisation to the plasma membrane of NaV1.5 promoted by the ß2 subunit is defective due to a ß2 mutation associated with Brugada syndrome. Biol. Cell 2017 Jul; 109 (7): 273-291                                                                                                     *equal contribution

- Verges, M. Retromer in polarized protein transport. Int. Rev. Cell Mol. Biol. 2016 Feb; 323 (5): 129-179 (Review)

- Mellado, M., Cuartero, Y., Brugada, R., and Verges, M. Subcellular localization of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells. Biol. Cell 2014 Nov; 106 (11): 377-393

- Riuró, H. et al. A missense mutation in the sodium channel ß2 subunit reveals SCN2b as a new candidate gene for Brugada syndrome. Hum Mutat. 2013 Jul; 34 (7): 961-966

- Cuartero, Y., Mellado, M., Capell, A., Álvarez-Dolado, M., and Verges, M. Retromer Regulates Postendocytic Sorting of ß-Secretase in Polarized Madin–Darby Canine Kidney Cells. Traffic 2012 Oct; 13 (10): 1393-1410

- Su, T. et al. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat. Cell Biol. 2010 Dec; 12 (12): 1143-1153

- Fuster, J.J. et al. (Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6. FASEB J. 2010 Aug; 24 (8): 2998-3009

C.2. Research projects and grants – in the last years

- Cardiac arrhythmias: causes and mechanisms; funded by the Fundación Española para la Ciencia y la Tecnología (FECYT), through the crowdfunding platform Precipita (Ref. PR220), 2019/01-2020/03: 2,501.03 €

- Support program for the development of the university professor’s professional career, funded by the UdG (Ref: 32.24.041), 2017/01-2018/11: 1,553 €

- Regulation of trafficking of the cardiac voltage-gated sodium channel, funded by the UdG – Grants to Improve the Scientific Productivity of research groups (Ref: MPCUdG2016), 2016/01-2018/12: 7,500 €

- Intracellular trafficking and localization of the cardiac sodium channel - alterations in heart disease, funded by the UdG – Grants for Outstanding Actions (Ref: SING 12/23), 2013/04-2013/03: 1,330 €

C.3. Participation in research meetings – in the last years

- Mellado, M., Cuartero, Y., Brugada, R., and Vergés, M. Subcellular location of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells. Zing Conference on Lysosome Related Organelles, Poster: Nerja (Spain) – Feb 2014

- Alcalde, M., Campuzano, O., Beltran-Alvarez, P., Pagans, S., Vergés, M., and Brugada, R. Role of truncated plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy. Frontiers in Cardiovascular Biology 2014, Oral Communication / M. Alcalde: Barcelona (Spain) – Jul 2014

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Effects of the D211G mutation on membrane dynamics of the cardiac voltage-gated sodium channel ß2 subunit. 4th GenCardio PhD Student Retreat - UdG / IDIBGI, Oral Communication / E. Cortada: Girona (Spain) – Oct 2015

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Effects of the D211G mutation on membrane dynamics of the cardiac voltage-gated sodium channel ß2 subunit. 5th Workshop: Structure and Function of Ion Channels and Transporters - Univ. of Lisbon, Poster: Lisbon (Portugal) – Nov 2015

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Effects of the D211G mutation on membrane dynamics of the cardiac voltage-gated sodium channel ß2 subunit. 1st Conference of the PhD Program in Molecular Biology, Biomedicine & Health - UdG, Oral Communication / E. Cortada: Girona (Spain) – Jan 2016

- Cortada, E., Serradesanferm, R., Brugada, R., and Vergés, M. Trafficking of the sodium channel ß2 subunit in polarized cells. EMBO Conference on Cell polarity and Membrane Dynamics, Poster: San Feliu de Guíxols (Spain) – June 2017

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Trafficking of the Sodium channel beta2 subunit in polarized cells. 1st Conference of UdG Predoctoral Researchers, Oral Communication / E. Cortada: Girona (Spain) – June 2017

- Cortada, E., Serradesanferm, R., Brugada, R., and Vergés, M. Trafficking and membrane dynamics of the sodium channel ß2 subunit. EMBO Workshop on Lysosomes & Metabolism, Poster: Naples (Italy) – May 2018

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Trafficking and membrane dynamics of the sodium channel ß2 subunit. 2nd Conference of UdG Predoctoral Researchers, Oral Communication / E. Cortada: Girona (Spain) – June 2018

- Cortada, E., Brugada, R., and Vergés, M. Trafficking of the cardiac voltage-gated sodium channel is dependent on N-glycosylation of its ß2 subunit. 7th Meeting of the Ion Channels Spanish Network (RECI VII), Poster: Cáceres (Spain) – May 2019

- Cortada, E., Brugada, R., and Vergés, M. Trafficking of the cardiac voltage-gated sodium channel is promoted by N-glycosylation of its ß2 subunit. 3rd Conference of UdG Predoctoral Researchers, Oral Communication / E. Cortada: Girona (Spain) – June 2019

- Cortada, E., Serradesanferm, R., Colomo, M., Pulido, I., Brugada, R., and Vergés, M. The sodium channel ß2 subunit relies on cholesterol to remain at the top of the cell. 4th Conference of UdG Predoctoral Researchers, Oral Communication / E. Cortada: Girona (Spain) – July 2020

- Colomo, M., Cortada, Brugada, R., and Vergés, M. The sodium channel ß2 subunit localizes to lipid rafts. 4th Conference of UdG Predoctoral Researchers, Oral Communication / E. Cortada: Girona (Spain) – July 2020

C.4. Other research merits

- Guest editor of the Special Issue on Trafficking of Cardiac Ion Channels - Mechanisms and Alterations Leading to Disease, for Biomolecules (ISSN 2218-273X), MDPI – 2019-2020

- Referee (since 2005): > 30 manuscripts reviewed in Acta Physiol. (Oxf): 3, Biol. Bull., Biomolecules, FASEB J., FEBS J., Int. J. Mol. Sci., Mol. Biol. Cell, Mol. Cell. Biol., Membranes, Mol. Microbiol., Nat. Commun.; verified by Publons: 21 (since 2015; 7 in 2020)

- Reviewer Board Member of MDPI; 8 manuscripts reviewed in MDPI journals

- External Evaluator since 2009: for the ANEP (MICINN, Spain), the FONCyT (MINCyT, Argentina), the European Research Council (European Union), the (ACSUCYL, Castilla y León), and the French National Research Agency (ANR, France).

- Member of the selection committees of UdG Teaching and Research Staff (since 2011)

- Member of Thesis (since 2009) & Master’s Committees (since 2016)

 

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