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Identificació

Estudia a la UdG

Dades generals

Curs acadèmic:
2020
Descripció:
L'objectiu fonamental de l'assignatura es l'estudi dels productes naturals, la seva biosíntesi i importància tant desde el punt de vista químic com de les seves aplicacions. Es posa èmfasi en les aplicacions biotecnològiques aplicades a la química.
Crèdits ECTS:
3

Grups

Grup QM

Durada:
Semestral, 1r semestre
Professorat:
EDUARD BARDAJI RODRIGUEZ
Idioma de les classes:
Anglès (100%)

Competències

  • Capacitat per analitzar críticament a partir de la recollida d'informació i la interpretació de dades , situacions complexes i dissenyar estratègies creatives i innovadores per resoldre-les.
  • Capacitat per actuar, generar propostes i prendre decisions en la investigació i en l'activitat professional amb criteris ètics i de sostenibilitat.
  • Aplicar els fonaments científics i el mètode científic ( reunir i gestionar dades per formular i comprovar hipòtesis ) per analitzar i explicar l'objecte d'estudi de la disciplina.
  • Aplicar els principis i teories de la reactivitat química a l'estudi dels compostos orgànics i inorgànics i al desenvolupament dels processos.
  • Integrar els coneixements del grau en un entorn professional i d'investigació incorporant coneixements de legislació , economia i gestió.

Continguts

1. Natural Products. Introduction, definition and structural classification from biosynthetic routes. General aspects: isolation, structural elucidation, elucidation of biosynthetic routes. Biomimetic syntheses, semisynthesis, enzymatic and chemoenzymatic synthesis. Bioproduction.

2. Lipids from Fatty acids.Glycerides and related compounds.

3. Polyketides. The role of Acyl-CoA intermediates. Polyphenols, polyethers, macrolides and polyketides.

4. Terpenes. Mevalonate and DXP routes to Isoprenoid precurssors: DMAPP and IPP. Monoterpenes. Sesquiterpenes. Diterpenes. Triterpenes.

5. Steroids. Origin from Triterpenes. Structural specificity, biological roles. Hemishyntesis and biocatalysis.

6. Carotenoids. Origin from Tetraterpenes. Structural specificity, biological roles.

7. Shikimic Acid and related metabolic precurssors. Natural products derived from Shikimate. ArC3, ArC1, ArcC2, Polyphenols, Lignanes, Cinnamic acids, and related compounds.

8. Alkaloids. Origin from aminoacids, subfamilies. Orn, Lys, Tyr, Phe, Trp derived alkaloids. Antranilates. Other producys derived from aminoacids: betalactams, etc.

9. Carbohydrates. Structural classification and biological roles. Aplications

10. Peptides and Proteins. Structural classification and biological roles. Aplications

11. Nucleosides and Nucleotides. Structural classification and biological roles. Aplications

12. BIOSYNTHESIS: Study of examples of biosynthesis of natural products with mechanistic detail from the bioorganic point of view.

13. Selected applications of natural products associated to biosynthetic knowledge. Examples of use a natural products in industry, enzymatic applications, bioproductions,etc.

Activitats

Tipus d’activitat Hores amb professor Hores sense professor Hores virtuals amb professor Total
Anàlisi / estudi de casos 4,00 15,00 10,00 29,00
Elaboració individual de treballs 11,00 20,00 15,00 46,00
Total 15,00 35,00 25,00 75

Bibliografia

Avaluació i qualificació

Activitats d'avaluació:

Descripció de l'activitat Avaluació de l'activitat % Recuperable
Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:


1. First Part. NATURAL PRODUCT FAMILIES. Its realization leads to obtain a maximum qualification of 6. For each NP family studied, according tothe provided template, the student must search and provide a natural product example. 10 examples in total.



The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).

Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:
1. First Part. NATURAL PRODUCT FAMILIES. Its realization leads to obtain a maximum qualification of 6. For each NP family studied, following the provided template, the student must search and provide an example and submit the corresponding questionnaire in pdf within three working days after having closed the study of the topic, either face-to-face or virtual.
60
Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:


2. Part Two. BIOSYNTHESIS. This part leads to obtain a maximum qualification of 8.5 without MH mention. The student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).


Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
2. Part Two. BIOSYNTHESIS. This part leads to obtain a maximum qualification of 8.5 without MH mention. The student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).
25
Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:



3. Part Three. BIOAPPLICATIONS. This part leads to obtain a maximum qualification of 10 with MH mention. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc.
The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).

Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
3. Part Three. BIOAPPLICATIONS. This part leads to obtain a maximum qualification of 10 with MH mention. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).
15

Qualificació

Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:
1. First Part. NATURAL PRODUCT FAMILIES. Its realization leads to obtain a maximum qualification of 6. For each NP family studied, following the provided template, the student must search and provide an example and submit the corresponding questionnaire in pdf within three working days after having closed the study of the topic, either face-to-face or virtual. 2. Part Two. BIOSYNTHESIS. This part leads to obtain a maximum qualification of 8.5 without MH mention. The student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).
3. Part Three. BIOAPPLICATIONS. This part leads to obtain a maximum qualification of 10 with MH mention. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).

Criteris específics de la nota «No Presentat»:
Do not present the work under any circumstances, or do not make the oral defense if the organizational conditions allow it.

Avaluació única:
Students must prepare personal work throughout the course and present it orally at the end (in a face-to-face or virtual session).
The qualifications of the work are grouped into three parts:
1. First Part. NATURAL PRODUCT FAMILIES. Its realization leads to obtain a maximum qualification of 6. For each NP family studied, according tothe provided template, the student must search and provide a natural product example. 10 examples in total.
2. Part Two. BIOSYNTHESIS. This part leads to obtain a maximum qualification of 8.5 without MH mention. The student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).
3. Part Three. BIOAPPLICATIONS. This part leads to obtain a maximum qualification of 10 with MH mention. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).
Under this modality, evaluation is unique, with a total qualification representing 100% of it.

Requisits mínims per aprovar:
To be considered to have passed the subject, a minimum grade of 5.0 must be obtained

Tutoria

Preferred tutorial interactions will be done using online communication channel, email to eduard.bardaji@udg.edu, and possible videoconnection afterwards.
Always detail on the subject PNAT2020-.......
Some communications will be posted on Moodle.

Comunicacio i interacció amb l'estudiantat

Communications will be done using online channels, email to eduard.bardaji@udg.edu, and possible videoconnections are possible.
Always detail on the emails subject PNAT2020-.......
Some communications will be posted on Moodle.

Observacions

Orientative material can be found at: http://www.eduardbardaji.com
Other material will be shared via Moodle.

Modificació del disseny

Modificació de les activitats:
Activities are already planned to be compatible with a virtual period. All exceptional situations will be attended.
Under any situation,either group or personal due management of activities will be done through moodle and email. Also meeting platforms will be used to connect.

Modificació de l'avaluació:
Qualification is already planned to be compatible with a virtual period.

Tutoria i comunicació:
Preferred communication channel, email to eduard.bardaji@udg.edu.
Always detail on the subject PNAT2020-.......
Some communications will be posted on Moodle.