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Dades generals

Curs acadèmic:
2023
Descripció:
L'objectiu fonamental de l'assignatura es l'estudi dels productes naturals, la seva biosíntesi i importància tant desde el punt de vista químic com de les seves aplicacions. Es posa èmfasi en les aplicacions biotecnològiques aplicades a la química.
Crèdits ECTS:
3

Grups

Competències

  • Capacitat per analitzar críticament a partir de la recollida d'informació i la interpretació de dades , situacions complexes i dissenyar estratègies creatives i innovadores per resoldre-les
  • Capacitat per actuar, generar propostes i prendre decisions en la investigació i en l'activitat professional amb criteris ètics i de sostenibilitat
  • Aplicar els fonaments científics i el mètode científic ( reunir i gestionar dades per formular i comprovar hipòtesis ) per analitzar i explicar l'objecte d'estudi de la disciplina
  • Aplicar els principis i teories de la reactivitat química a l'estudi dels compostos orgànics i inorgànics i al desenvolupament dels processos
  • Integrar els coneixements del grau en un entorn professional i d'investigació incorporant coneixements de legislació , economia i gestió

Continguts

1. Natural Products. Introduction, definition and structural classification from biosynthetic routes. General aspects: isolation, structural elucidation, elucidation of biosynthetic routes. Biomimetic syntheses, semisynthesis, enzymatic and chemoenzymatic synthesis. Bioproduction.

2. Lipids from Fatty acids.Glycerides and related compounds.

3. Polyketides. The role of Acyl-CoA intermediates. Polyphenols, polyethers, macrolides and polyketides.

4. Terpenes. Mevalonate and DXP routes to Isoprenoid precurssors: DMAPP and IPP. Monoterpenes. Sesquiterpenes. Diterpenes. Triterpenes.

5. Steroids. Origin from Triterpenes. Structural specificity, biological roles. Hemishyntesis and biocatalysis.

6. Carotenoids. Origin from Tetraterpenes. Structural specificity, biological roles.

7. Shikimic Acid and related metabolic precurssors. Natural products derived from Shikimate. ArC3, ArC1, ArcC2, Polyphenols, Lignanes, Cinnamic acids, and related compounds.

8. Alkaloids. Origin from aminoacids, subfamilies. Orn, Lys, Tyr, Phe, Trp derived alkaloids. Antranilates. Other producys derived from aminoacids: betalactams, etc.

9. Carbohydrates. Structural classification and biological roles. Aplications

10. Peptides and Proteins. Structural classification and biological roles. Aplications

11. Nucleosides and Nucleotides. Structural classification and biological roles. Aplications

12. BIOSYNTHESIS: Study of examples of biosynthesis of natural products with mechanistic detail from the bioorganic point of view.

13. Selected applications of natural products associated to biosynthetic knowledge. Examples of use a natural products in industry, enzymatic applications, bioproductions,etc.

Activitats

Tipus d’activitat Hores amb professor Hores sense professor Hores virtuals amb professor Total
Anàlisi / estudi de casos 4,00 15,00 10,00 29,00
Elaboració individual de treballs 11,00 20,00 15,00 46,00
Total 15,00 35,00 25,00 75

Bibliografia

Avaluació i qualificació

Activitats d'avaluació:

Descripció de l'activitat Avaluació de l'activitat % Recuperable

First Part. NATURAL PRODUCT FAMILIES. This part is dedicated to the study of different families of Natural Products classified from a biogenetic point of view. Students should be able to classify and differentiate Natural Products under these bases. This part accounts for the 75% of the total qualification and will be evaluated in written test. (Not Oral Presentations in this part).

First Part. NATURAL PRODUCT FAMILIES. This part is dedicated to the study of different families of Natural Products classified from a biogenetic point of view. Students should be able to classify and differentiate Natural Products under these bases. This part accounts for the 75% of the total qualification and will be evaluated in written test. (Not Oral Presentations in this part).


75


2. Part Two. BIOSYNTHESIS. This part is dedicated to study in detail some Biosynthetic Examples of Natural Products. Students should understant the bioorganic mechanisms and the catalytic role of enzymes from a organic chemistry mechanistic point of view. This part accounts for the 15% of the total qualification and will be evaluated in an optative Oral Presentation


2. Part Two. BIOSYNTHESIS. This part accounts for the 15% of the total qualification and will be evaluated in an optative Oral Presentation. The student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the enzymatic and bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference). 15


3. Part Three. BIOAPPLICATIONS. This part is dedicated to different applications of natural products and the associated biosynthetic knowledge, in any fields: use of a natural products in industry as raw materials, enzymatic applications, bioproduction or biological engineering, waste valorization from natural sources, etc. This part accounts for the 10% of the total qualification and will be evaluated in an optative Oral Presentation



3. Part Three. BIOAPPLICATIONS. This part leads to obtain a maximum qualification of 10 with MH mention. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference). 10

Qualificació

First Part. NATURAL PRODUCT FAMILIES. This part is dedicated to the study of different families of Natural Products classified from a biogenetic point of view. Students should be able to classify and differentiate Natural Products under these bases. This part accounts for the 75% of the total qualification and will be evaluated in written test. (Not Oral Presentations in this part).
2. Part Two. BIOSYNTHESIS. This part is dedicated to study in detail some Biosynthetic Examples of Natural Products. Students should understant the bioorganic mechanisms and the catalytic role of enzymes from a organic chemistry mechanistic point of view. This part accounts for the 15% of the total qualification and will be evaluated in an optative Oral Presentation.
3. Part Three. BIOAPPLICATIONS. This part is dedicated to different applications of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry as raw materials, enzymatic applications, bioproduction or biological engineering, waste valorization from natural sources, etc. This part accounts for the 10% of the total qualification and will be evaluated in an optative Oral Presentation

Criteris específics de la nota «No Presentat»:
Do not present the work under any circumstances, or do not make the oral defense if the organizational conditions allow it.

Avaluació única:
1. First Part. NATURAL PRODUCT FAMILIES. Written text. 75% of total qualification.

2. Students must prepare personal work throughout the course and make an oral presentation followed by some oral questions (this parts are individual and optative)
The individual presentations can have one or two parts:
a) BIOSYNTHESIS. Student prepares a presentation on the biosynthesis of a natural product with mechanistic detail from the bioorganic point of view. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference). 15% of total qualification.
b)BIOAPPLICATIONS. Student prepares a presentation or work (depending on organizational conditions) of a case of application of natural products and the associated biosynthetic knowledge, in any field: use of a natural products in industry, enzymatic applications, bioproduction, of a natural product, waste utilization with natural products etc. The evaluation can be face-to-face (oral presentation) or virtual (pdf and videoconference).10% of total qualification.

Requisits mínims per aprovar:
To be considered to have passed the subject, a minimum grade of 5.0 must be obtained

Tutoria

Preferred tutorial interactions will be done using online communication channel, email to eduard.bardaji@udg.edu, and possible videoconnection afterwards.
Always writte emails with the subject starting with PNAT2022-.......and add your additional info, that makes easy to find emails sent from adresses that goes to spam folder.
Essential information, materials and communications will be posted on the Moodle.

Comunicacio i interacció amb l'estudiantat

Relevant and essential communications will be posted on Moodle.

Specific communications will be done by email to eduard.bardaji@udg.edu, and if necessary through videoconnection.

Always writte on the subject of your emails PNAT2022-.......

Observacions

Basic and Orientative materials can be found at: http://www.eduardbardaji.com - docencia - productes naturals
Other material will be shared via Moodle.

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