Universitat de Girona > Directori > Pàgina personal
Anar al contingut (clic a Intro)
UdG Home UdG Home
Tancar
Menú

Dr.  Verges Aiguaviva, Marcel

Plana personal

Categoria
PROFESSOR AGREGAT
Departament
CIÈNCIES MÈDIQUES
Àrea de coneixement
MEDICINA
Grup de recerca
Grup de Recerca en Genètica Cardiovascular
ORCID PRC:
0000-0002-2606-223X

Currículum abreujat

 

CV date

June 19, 2021

A. PERSONAL AND PROFESSIONAL INFORMATION

First and Family name

Marcel Vergés

 

Social Security, Passport, ID number

40462407W

Age

55

Researcher codes

WoS Researcher ID

L-5784-2014

 

SCOPUS Author ID

6603954505

 

Open Researcher and Contributor ID (ORCID)

0000-0002-2606-223X

 

           

A.1. Current position

Name of University/Institution

Univ. of Girona (UdG)

Department

Medical Sciences 

Address and Country

Emili Grahit 77 – 2nd fl., 17071 – Girona, Spain

Phone: +34 606 726173;

+34 872 987087 Ext. 62

E-mail: marcel.verges@udg.edu; mverges@gencardio.com

 

Current position

Associate Professor

From

2015

Key words

cardiac arrhythmias; protein trafficking; voltage-gated sodium channel; NaV1.5; SCN2B

         

A.2. Education

PhD

University

Year

Biological Sciences

Univ. of Barcelona (UB)

1994

A.3. JCR articles, h Index, thesis supervised…

Publications and citation report:

33 publications (WoS)

28 results in PubMed

Number of articles as first or senior (corresponding) author: 17

Citations: 949, by 818 documents (SCOPUS)

Avg. citations / year (publons): 29

Avg. citations / item (publons): 31

Num. of publ. in top Quartile (WoS): 21 (at year of publication)

Number of publ. in top Decile (WoS): 10

H-index (publons): 13; H-index (SCOPUS): 14

Theses supervised:

. Yasmina Cuartero (CIPF - Univ. of Valencia): Función del retromer en el tráfico de β-secretasa y de la proteína precursora del péptido β-amiloide en células polarizadas MDCK - 2012 - Sobresaliente Cum laude - fellowship CIPF PR 01/2007 (2007-2010)

. Eric Cortada (GenCardio, IDIBGI - UdG): Trafficking and function of the voltage-gated sodium channel β2 subunit - 2020 - Cum laude with International distinction - fellowship AGAUR (Generalitat de Catalunya) 2017 FI_B 00071 (2017-2020).

 

B. CV SUMMARY

The topic of my doctoral thesis (Dep. of Cell Biology – UB School of Medicine) focused on dissecting the endocytic pathway in polarized cells using rat liver as a model; my PhD adviser was Prof. C. Enrich (Biochem. Biophys. Res. Commun. 1997).

In 1995, I began a postdoctoral stay at the Univ. of California San Francisco – Cardiovascular Research Inst., under the joint supervision of Prof’s. R. Havel & K. Mostov, the latter, of the Anatomy Dep. With Prof. Havel, I focused on lipoprotein uptake and trafficking in hepatocytes, using rat and knockout mice as model systems (Proc. Natl. Acad. Sci. U.S.A. 1999; J. Biol. Chem. 2004). In 1999, I joined the Mostov lab, focusing on regulation of transcytosis in polarized cells (Mol. Cell 1999). Our results contributed to a better understanding of polarized trafficking, demonstrating the role by retromer in mediating polarized protein sorting at the endosome (Nat. Cell Biol. 2004).

In 2004, through a Ramón y Cajal contract, I started up my own lab at the Centro de Investigación Príncipe Felipe (CIPF) in Valencia. There, I continued with my efforts to elucidate the mechanisms by which retromer regulates polarized sorting (Exp. Cell Res. 2007; Front. Biosci. 2007; Int. Rev. Cell Mol. Biol. 2008). In 2008, ANEP issued a favorable report on my research career within the I3 Program, while my mind was already focused on the medical studies project that had just started at the UdG.

In 2010, I obtained a position as tenure-track Lecturer at the UdG School of Med and, as a senior researcher, I also joined GenCardio, a large group led by Prof. R. Brugada at the Girona Biomedical Research Institute (IDIBGI).

Then, Dr. Yasmina Cuartero (Traffic 2012) defended her thesis, still carried out at the CIPF; her results helped to better understand the link of sorting defects by retromer and generation of the β-amyloid peptide, as cause and aggravating factor of Alzheimer's disease. For a while, I still continued interested in analyzing localization of retromer and its function in polarized trafficking (Biol. Cell 2014; Int. Rev. Cell Mol. Biol. 2015).

At GenCardio, I collaborated with Dr. H. Riuró during her thesis. We showed for the first time the association with Brugada syndrome (BrS) of SCN2B, the gene encoding the voltage-gated sodium (NaV) channel β2 subunit (Hum. Mutat. 2013); BrS patients display cardiac arrhythmia that can lead to sudden death. Subsequently (Biol. Cell 2017), we achieved a better understanding on why β2 D211G – the BrS-associated mutant – is defective in promoting localization to the cell surface of NaV1.5, the major NaV isoform in the heart. Evidence of my interest on this area of research is my implication in reviewing and commenting on related work (Acta Physiol. 2017; Biomolecules 2019; Acta Physiol. 2020; Acta Physiol. 2020).

During the last years, I have achieved a positive evaluation of research activity on 3 sexennial periods by AQU Catalunya. Also, in 2015, I received accreditation by the AQU to be hired as Associate Prof., and similarly by the ANECA; indeed, in July 2019, and through public examination, I was appointed permanent faculty as Associate Prof. for the UdG at the Medical Sciences Dep. (Area of Medicine).

In recent years, I have supervised 7 master’s and 7 undergraduate' students, and more are underway. Recently, Dr. Eric Cortada defended his thesis under my supervision. He showed the key importance of β2 N-glycosylation in its trafficking and in promoting NaV1.5 localization to the plasma membrane. In his latest achievement (J. Biol. Chem. 2019). Next, Eric demonstrated that β2 S-palmitoilación increases its affinity for cholesterol-enriched lipid raft domains and regulates the polarized surface localization of β2 (J. Cell Sci. 2021). The mechanisms analyzed by Eric are fundamental for cardiac function, since possible alterations can affect cell excitability and electrical coupling of the heart.

Regarding Eric’s career in science, he spent 3 months at the lab of Prof. Lori Isom, from the Univ. of Michigan (Ann Arbor, MI), supported by the UdG and the AGAUR (2019). There, he studied the function of β2 in cardiomyocytes of Scn2b knockout mice. Recently, he began a postdoctoral stay at the lab of Prof. James C. Lo, in Cornell University (Ithaca, NY) investigating molecular mechanisms of cardiac and metabolic diseases.

C. RESEARCH MERITS

C.1. Publications (including books) in the last 10 years

- Trafficking of Cardiac Ion Channels - Mechanisms and Alterations Leading to Disease. April 2021; Printed Edition of the Special Issue Published in Biomolecules (Edited by M. Verges); ISBN 978-3-03943-473-2

- Cortada E., Serradesanferm R., Brugada R., and Verges M. The voltage-gated sodium channel β2 subunit associates with lipid rafts by S-palmitoylation. J Cell Sci. 2021. Mar 26; 134 (6): jcs252189

- Cortada, E. and Verges, M. NaV1.5 in embryonic heart development. Acta Physiol. (Oxf) 2020 Oct; 230 (2): e13542 (Editorial)

- Cortada, E. and Verges, M. Alterations in ubiquitin-mediated degradation of NaV1.5 can cause arrhythmia. Acta Physiol. (Oxf) 2020 Jun; 229 (2): e13459 (Editorial)

- Cortada, E., Brugada, R., and Verges, M. Trafficking and function of the voltage-gated sodium channel β2 subunit. Biomolecules 2019 Oct 13; 9 (10): E604 (Review)

- Cortada, E., Brugada, R., and Verges, M. (N-glycosylation of the voltage-gated sodium channel β2 subunit is required for efficient trafficking of NaV1.5/ β2 to the plasma membrane. J. Biol. Chem. 2019 Nov 1; 294 (44): 16123-16140

- Pagans S., and Vergés M. (2017) A mechanism for NaV1.5 downregulation and sodium current decrease in heart failure. Acta Physiol. (Oxf) 2017 Sep; 221(1): 11-13 (Editorial)

- Dulsat, G.*, Palomeras, S.*, Cortada, E.*, Riuró, H., Brugada, R., and Vergés, M. Trafficking and localisation to the plasma membrane of NaV1.5 promoted by the β2 subunit is defective due to a β2 mutation associated with Brugada syndrome. Biol. Cell 2017 Jul; 109 (7): 273-291                                                                                                     *equal contribution

- Verges, M. Retromer in polarized protein transport. Int. Rev. Cell Mol. Biol. 2016 Feb; 323 (5): 129-179 (Review)

- Mellado, M., Cuartero, Y., Brugada, R., and Verges, M. Subcellular localization of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells. Biol. Cell 2014 Nov; 106 (11): 377-393

- Riuró, H. et al. A missense mutation in the sodium channel β2 subunit reveals SCN2b as a new candidate gene for Brugada syndrome. Hum Mutat. 2013 Jul; 34 (7): 961-966

- Cuartero, Y., Mellado, M., Capell, A., Álvarez-Dolado, M., and Verges, M. Retromer Regulates Postendocytic Sorting of β-Secretase in Polarized Madin–Darby Canine Kidney Cells. Traffic 2012 Oct; 13 (10): 1393-1410

- Su, T. et al. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat. Cell Biol. 2010 Dec; 12 (12): 1143-1153

- Fuster, J.J. et al. (Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6. FASEB J. 2010 Aug; 24 (8): 2998-3009

C.2. Projects and grants in the last years as a PI

- Cardiac arrhythmias: causes and mechanisms; funded by the Fundación Española para la Ciencia y la Tecnología (FECYT), through the crowdfunding platform Precipita (Ref. PR220), 2019/01-2020/03: 2,501.03 €

- Support program for the development of the university professor’s professional career, funded by the UdG (Ref: 32.24.041), 2017/01-2018/11: 1,553 €

- Regulation of trafficking of the cardiac voltage-gated sodium channel, funded by the UdG – Grants to Improve the Scientific Productivity of research groups (Ref: MPCUdG2016), 2016/01-2018/12: 7,500 €

- Intracellular trafficking and localization of the cardiac sodium channel - alterations in heart disease, funded by the UdG – Grants for Outstanding Actions (Ref: SING 12/23), 2013/04-2013/03: 1,330 €

C.3. Participation in International meetings in the last years

- Mellado, M., Cuartero, Y., Brugada, R., and Vergés, M. Subcellular location of retromer in postendocytic pathways of polarized Madin-Darby canine kidney cells. Zing Conference on Lysosome Related Organelles, Poster: Nerja (Spain) – Feb 2014

- Alcalde, M., Campuzano, O., Beltran-Alvarez, P., Pagans, S., Vergés, M., and Brugada, R. Role of truncated plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy. Frontiers in Cardiovascular Biology 2014, Oral Communication, by M. Alcalde: Barcelona (Spain) – Jul 2014

- Cortada, E., Serradesanferm, R., Riuró, H., Brugada, R., and Vergés, M. Effects of the D211G mutation on membrane dynamics of the cardiac voltage-gated sodium channel β2 subunit. 5th Workshop: Structure and Function of Ion Channels and Transporters - Univ. of Lisbon, Poster: Lisbon (Portugal) – Nov 2015

- Cortada, E., Serradesanferm, R., Brugada, R., and Vergés, M. Trafficking of the sodium channel β2 subunit in polarized cells. EMBO Conference on Cell polarity and Membrane Dynamics, Poster: San Feliu de Guíxols (Spain) – June 2017

- Cortada, E., Serradesanferm, R., Brugada, R., and Vergés, M. Trafficking and membrane dynamics of the sodium channel β2 subunit. EMBO Workshop on Lysosomes & Metabolism, Poster: Naples (Italy) – May 2018

- Cortada, E., Brugada, R., and Vergés, M. Trafficking of the cardiac voltage-gated sodium channel is dependent on N-glycosylation of its β2 subunit. 7th Meeting of the Ion Channels Spanish Network (RECI VII), Poster: Cáceres (Spain) – May 2019

C.4. Other merits

- Guest editor of the Special Issue on Trafficking of Cardiac Ion Channels - Mechanisms and Alterations Leading to Disease, for Biomolecules (ISSN 2218-273X), MDPI – 2019-2020

- Referee (since 2005): > 30 manuscripts reviewed in Indexed journals, 24 verified by publons (since 2015)

- Reviewer Board Member of MDPI; 10 manuscripts reviewed in MDPI journals

- External Evaluator (since 2009): ANEP (MICINN, Spain), FONCyT (MINCyT, Argentina), European Research Council (EU), ACSUCYL (Castilla y León), and French National Research Agency (ANR, France).

- Member of selection committees for the UdG Teaching and Research Staff (since 2011)

- Member of Thesis (since 2009) & Master’s Committees (since 2016)

D. TEACHING MERITS

C.1. Teaching Education Articles

- Vergés M. and Massaguer A. Relación entre la calificación en las sesiones ABP con la de exámenes tipo ABP, test y la nota final. From the VIII Jornadas de Docencia de la Biología Celular by the Sociedad Española de Biología Celular (Girona, 2016) Abstracts Book: p.25 (O15): Oral Communication

- Vergés, M. Correlation between scores in PBL sessions with those in PBL exams, multiple-choice tests, and the final qualification, in first-year medical students taking an integrative biology module. In: INTED Proceedings from the International Academy of Technology, Education and Development (IATED) conference (Valencia, 2017), ed. by Gómez, L., López, A., and Candel, I., pp. 7841-7848. ISBN / ISSN: 978-84-617-8491-2 / 2340-1079: Poster

- Vergés, M. A survey to night-shift nurses analyzed by medical students. In: INTED Proceedings from the International Academy of Technology, Education and Development (IATED) conference (Valencia, 2018), ed. by Gómez, L., López, A., and Candel, I., pp. 1107-1116. ISBN / ISSN: 978-84-697-9480-7 / 2340-1079: Oral Communication

C.2. Projects and grants

- Foment de la interdisciplinarietat i la internacionalització en els estudis de Medicina. Funded by the UdG – Program to promote innovation in teaching and improvement of the quality of teaching (Ref. MIQD UdG 107/17). PI: F. S. Scornik, 2017/12–2018/12: 3.620,76 €

C.3. Teaching innovation and other teaching activity

- Participant of the Teaching Innovation Network in Tutoring (UdG) – ICE Josep Pallach: since January 2017 (date of establishment); Coordination since January 2019.

- Creation and coordination of the elective subject: Chronomedicine (3109G01075) – School of Medicine, UdG: from the academic year 2017–2018

- Coordination of the elective subject: Biological basis of cardiovascular diseases, from the Master in Molecular Biology and Biomedicine (UdG): from the academic year 2019–2020

C.4. Experience in educational administration, management and leadership

- Chair at the Parent-Teacher Associations (AMPA), and School Board representative of the Sant Cristòfol public school, Les Planes d'Hostoles (Girona): June 2013 - June 2017

- School Board parents representative of the Castell d'Estela high school, Amer (Girona): since Oct. 2018

 

Escull quins tipus de galetes acceptes que el web de la Universitat de Girona pugui guardar en el teu navegador.

Les imprescindibles per facilitar la vostra connexió. No hi ha opció d'inhabilitar-les, atès que són les necessàries pel funcionament del lloc web.

Permeten recordar les vostres opcions (per exemple llengua o regió des de la qual accediu), per tal de proporcionar-vos serveis avançats.

Proporcionen informació estadística i permeten millorar els serveis. Utilitzem cookies de Google Analytics que podeu desactivar instal·lant-vos aquest plugin.

Per a oferir continguts publicitaris relacionats amb els interessos de l'usuari, bé directament, bé per mitjà de tercers (“adservers”). Cal activar-les si vols veure els vídeos de Youtube incrustats en el web de la Universitat de Girona.