Activitats de caràcter científic o professional
2001-2010 Professor Associat Tipus 2, a temps complet Universitat de GironA
02-09/2010 Professor Associat Tipus 3, a temps complet Universitat de Girona
09/2010-11/2011 Investigador Post-Doc, a temps complet UNIVERSITÉ D’AUVERGNE
11/2012-11/2016 Professor Lector Universitat de Girona
Des de 11/2016 Professor Agregat interí Universitat de Girona
UNIVERSITAT DE GIRONAFormació acadèmica
LLiCENCIADA EN BIOLOGIA, UNIVERSITAT DE GIRONA, 2001
DIPLOMA ESTUDIS AVANÇATS, UNIVERSITAT DE GIRONA, 2003
Títol: Anàlisi i enriquiment de bacteris verds del sofre bentònics de l’estanyol d’en Sisó. Director: Dr. Jesús Garcia Gil
DOCTORAT EN BIOLOGIA, UNIVERSITAT DE GIRONA, 2009
Títol: Intestinal Microbiology in Crohn’s Disease: A study of Escherichia coli as a potential etiologic agent. Director: Dr. Jesús Garcia Gil
Menció Europea
Premi Extraordinari de Doctorat en Biologia de l’any 2009 per la UdG
Premi millor tesi doctoral 2010 per l’IdIbGi
Acreditacions obtingudes
2011 Profesor Ayudante Doctor ANECA
2016 Profesor Contratado Doctor ANECA
2016 Professor Agregat AQU
Participació en projectes competitius
2017-2020
Búsqueda de nuevos factores implicados en la virulencia del patotipo AIEC asociado a la enfermedad de Crohn: estudio transcriptómico y rol de las vesículas de membrana externa. SAF2017-82261-P.
MINECO - Ministerio de Economía Indústria y Competitividad. Investigador/a principal: Margarita Martínez Medina y Jesús García Gil
2016-2018
Genòmica i transcriptòmica comparative per identificar gens implicats en el fenotip AIEC. MPCUdG2016/009.
VUDG - Universitat de Girona (UdG). Investigador/a principal: Margarita Martínez Medina
2014-2016
Determinantes genéticos implicados en el patotipo Escherichia coli adherente invasiva (AIEC) para su identificación en la enfermedad de Crohn. SAF2013-43284-P.
MECO - Ministerio de Economía y Competitividad. Investigador/a principal: Margarita Martínez Medina
2011 -2013
Escherichia coli Adherente Invasiva (AIEC): prevalencia en otras enfermedades intestinales diferentes de Crohn y determinantes genéticos implicados en su patogenicidad. SAF2010-15896.
Ministerio de Ciencia e Innovación. Investigador/a principal: Dr. L. Jesús Garcia Gil
2010-2012
Virulence de souches de Escherichia coli invasives dans un modèle murin mimant la susceptibilité des patients atteints de maladie de Crohn
Région Auvergne. Investigador/a principal: Dr. Nicolas Barnich
2007-2008
Desenvolupament i aplicació de sistemes de detecció molecular de bacteris per a la millora del diagnòstic de la pneumònia adquirida a la comunitat greu i el coneixement dels agents etiopatogèncics implicats
Fundació Privada Institut d’Investigació Biomèdica de Girona Dr. Josep Trueta. Investigador/a principal: Dr. L. Jesús Garcia Gil
2006-2009
Estudio de la microbiota asociada a la Enfermedad Inflamatoria Intestinal para la selección de marcadores bacterianos específicos y su aplicación al diagnóstico de la enfermedad de Crohn y colitis ulcerosa. SAF2006-00414.
Ministerio de Educación y Ciencia. Investigador/a principal: Dr. L. Jesús Garcia Gil
2003-2006
Diversidad de microorganismos Archea en ecosistemas acuáticos templados. Dinámica, actividad metabólica e impacto en el ciclo biogeoquímico del carbono. REN2003-08333-C02-01.
Ministerio de Ciencia y Tecnología. Investigador/a principal: Dr. Carles Borrego Moré
Publicacions
2019
Carla Camprubí-Font, Belén Ruiz del Castillo, Silvia Barrabés Vera, Luis Martinez Martinez, Margarita Martinez-Medina. Amino Acid Substitutions and Differential Gene Expression of Outer Membrane Proteins (2019) Frontiers in Microbiology DOI: 10.3389/fmicb.2019.01707
Camprubí-Font, C., Ewers, C., Lopez-Siles, M., Martinez-Medina, M. Genetic and phenotypic features to screen for putative adherent-invasive Escherichia coli (2019) Frontiers in Microbiology, 10, art. no. 108
Díaz-Rizzolo, D.A., Kostov, B., López-Siles, M., Serra, A., Colungo, C., González-de-Paz, L., Martinez-Medina, M., Sisó-Almirall, A., Gomis, R. Healthy dietary pattern and their corresponding gut microbiota profile are linked to a lower risk of type 2 diabetes, independent of the presence of obesity (2019) Clinical Nutrition.
Fassatoui, M., Lopez-Siles, M., Díaz-Rizzolo, D.A., Jmel, H., Naouali, C., Abdessalem, G., Chikhaoui, A., Nadal, B., Jamoussi, H., Abid, A., Gomis, R., Abdelhak, S., Martinez-Medina, M., Kefi, R. Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus (2019) Bioscience Reports, 39 (6), art. no. BSR20182348
2018
Lopez-Siles, M., Enrich-Capó, N., Aldeguer, X., Sabat-Mir, M., Duncan, S.H., Garcia-Gil, L.J., Martinez-Medina, M. Alterations in the Abundance and Co-occurrence of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Colonic Mucosa of Inflammatory Bowel Disease Subjects (2018) Frontiers in Cellular and Infection Microbiology, 8 (SEP), art. no. 281.
Camprubí-Font, C., Lopez-Siles, M., Ferrer-Guixeras, M., Niubó-Carulla, L., Abellà-Ametller, C., Garcia-Gil, L.J., Martinez-Medina, M. Comparative genomics reveals new single-nucleotide polymorphisms that can assist in identification of adherent-invasive Escherichia coli (2018) Scientific Reports, 8 (1), art. no. 2695
2017
Lopez-Siles, M., Duncan, S.H., Garcia-Gil, L.J., Martinez-Medina, M. Faecalibacterium prausnitzii: From microbiology to diagnostics and prognostics (2017) ISME Journal, 11 (4), pp. 841-852.
2016
Mireia Lopez Siles, Sylvia Duncan, Jesús Garcia-Gil, and Margarita Martinez-Medina. Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics. The ISME Journal. In press.
M Balfegó; S Canivell; F A. Hanzu; A Sala-Vila; M Martínez-Medina; S Murillo; T Mur; E G. Ruano; F Linares; N Porras; S Valladares; M Fontalba; E Roura; A Novials; C Hernández; G Aranda; A Sisó-Almirall; G Rojo-Martínez; R Simó; R Gomis. Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes: a pilot randomized trial. Apr 18;15:78. doi: 10.1186/s12944-016-0245-0.
J. Vila, E. Saez-Lopez, J. R. Johnson, U. Romling, U. Dobrindt, R. Canton, C. G. Giske, T. Naas, A. Carattoli, M. Martinez-Medina, J. Bosch, P. Retamar, J. Rodriguez-Bano, F. Baquero and S. M. Soto. Escherichia coli: an old friend with new tidings. Mar 8. pii: fuw005. [Epub ahead of print]
Agus A, Denizot J, Thévenot J, Martinez-Medina M, Massier S, Sauvanet P, Bernalier-Donadille A, Denis S, Hofman P, Bonnet R, Billard E, Barnich N. Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Scientific Reports 8(6): 19032
M. Lopez-Siles, M. Martinez-Medina, R. Surís-Valls, X. Aldeguer, M. Sabat-Mir, S. H. Duncan, H. J. Flint, and L. J. Garcia-Gil. Changes in the abundance of Faecalibacterium prausnitzii phylogroups I and II in the intestinal mucosa of inflammatory bowel disease and colorectal cancer patients. Inflammatory Bowel Diseases 22(1):28-41
2015
Lopez-Siles M, Martinez-Medina M, Abellà C, Busquets D, Sabat-Mir M, Duncan SH, Aldeguer X, Flint HJ, Garcia-Gil LJ. Mucosa-associated Faecalibacterium prausnitzii phylotype richness is reduced in patients with inflammatory bowel disease. Applied and Environmental Microbiology 81: 7582-7592
Busquets D, Mas-de-Xaxars T, López-Siles M, Martinez-Medina M, Bahí A, Sàbat M, Louvriex R, Miquel-Cusachs JO, Garcia-Gil JL, Aldeguer X. Anti-tumour Necrosis Factor Treatment with Adalimumab Induces Changes in the Microbiota of Crohn's Disease. Journal of Crohn's and Colitis 9: 899-906
Massart S, Martinez-Medina M, Jijakli H. Biological control in the microbiome era: Challenges and opportunities. Biological Control 89:98-108.
2014
Lopez-Siles M, Martinez-Medina M, Busquets D, Sabat-Mir M, Duncan S, Flint H, Aldeguer X, Garcia-Gil L. Mucosa-associatedFaecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes. Int J Med Microbiol 304(3-4): 464-475.
Martinez-Medina M, Denizot J, Dreux N, Robin F, Billard E, Bonnet R, Darfeuille-Michaud A, Barnich N. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut 2014;63(1):116-24.
2013
Dreux N, Denizot J, Martinez-Medina M, Mellmann A, Billig M, Kisiela D, Chattopadhyay S, Sokurenko E, Neut C, Gower-Rousseau C, Colombel J-F, Bonnet R, Darfeuille-Michaud A, Barnich N. Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response. PLoS Pathog 2013;9:e1003141
2011
Martinez-Medina M, Garcia-Gil J, Barnich N, Wieler LH, Ewers C. Adherent-Invasive Escherichia coli phenotype displayed by Intestinal Pathogenic E. coli Strains from cats, dogs, and swine. Applied and Envirnomental Microbiology 77(16): 5813–5817.
2009
Martinez-Medina M, Aldeguer X, Lopez-Siles M, González-Huix F, López-Oliu C, Dahbi G, Blanco JE, Blanco J, Garcia-Gil LJ, and Darfeuille-Michaud A. Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn’s disease. Inflammatory Bowel Diseases 15(6):872-882
Martinez-Medina M, Mora A, Blanco M, Lopez C, Alonso MP, Bonacorsi S, Nicolas-Chanoine M-H, Darfeuille-Michaud A, Garcia-Gil J, and Blanco J. Similarity and divergence among Adherent-Invasive Escherichia coli and Extraintestinal Pathogenic E. coli strains. Journal of Clinical Microbiology 47(12):3968-3979
Martinez-Medina M, Naves P, Blanco J, Aldeguer X, Blanco J, Blanco M, Ponte C, Soriano F, Darfeuille-Michaud A, and Garcia-Gil LJ. Biofilm formation as a novel phenotypic feature of adherent-invasive Escherichia coli (AIEC). BMC Microbiology 9(1):202
Bañeras L, Gich F, Martinez-Medina M, Miller M, Abella CA, and Borrego CM. New phylotypes of mesophilic filamentous anoxygenic phototrophic bacteria enriched from sulfide-containing environments. Environmental Microbiology Reports (1): 86-93
2008
Darfeuille-Michaud A, and Colombel JF. Secció d’aquesta revisió: Martinez-Medina M, Lopez-Siles M, Aldeguer X, Gonzalez-Huix F, Lopez-Oliu C, Blanco J, Darfeuille-Michaud A, and Garcia-Gil LJ. Pathogenic Escherichia coli in inflammatory bowel diseases. Proceedings of the 1st International Meeting on E. coli and IBD, June 2007, Lille, France. Secció d’aquesta revisió: Presentation 6: Prevalence and diversity of adherent invasive E. coli in Crohn's disease patients from Girona, Spain. Journal of Crohn's and Colitis, 2: 259
2006
Martinez-Medina M, Aldeguer X, Gonzalez-Huix F, Acero D, and Garcia-Gil LJ. Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis. Inflammatory Bowel Diseases 12(12):1136-1145
Estades en centres de recerca
Pre-doctorals
2005, durant 2 mesos: Veterinary Molecular Microbiology Pathogenesis Laboratory, University of Bristol, REGNE UNIT
2006-2007, durant 4,5 mesos: Laboratoire de Pathogénie Bacteriénne Intestinale, Université d'Auvergne, FRANÇA
Post-doctoral
2010, durant 1 any i 4 mesos: Laboratoire de Pathogénie Bacteriénne Intestinale, Université d'Auvergne, FRANÇA
Direcció de tesis doctorals
Doctorand: Mireia López Siles. Títol: Ecophysiology and phylogeny of Faecalibacterium prausnitzii in healthy and diseased gut. Application in Inflammatory Bowel Disease diagnostics. Any: 2016
Directors: Jesús Garcia Gil i Margarita Martínez Medina. Institució: Universitat de Girona.
Participacions més rellevants a congressos
Comunicacions orals
Carla Camprubí-Font, Mireia López-Siles, Meritxell Ferrer-Guixeras, Laura Niubo-Carulla, Carles Abellà-Ametller, Jesús Garcia-Gil, Margarita Martinez-Medina. Comparative genomics and single nucleotide polymorphism distribution between adhesrent-invasive Escherichia coli (AIEC) and non-AIEC strans from the human intestine. UEGW, Wien (Austria). 2016.
Martinez-Medina, M; E. coli and inflammatory bowel diseases . ESCMID Conference on Escherichia coli: An Old Friend with New Tidings., Barcelona (Spain). 2013. Invited talk.
Martinez-Medina, M; Denizot, J; Darfeuille- Michaud, A; Barnich, N. High fat diet favours AIEC colonization and inflammation in CEABAC10 mice by modulating microflora composition. 15th International Conference on Mucosal Immunology, Paris (France). 2011.
Martinez-Medina, M; Denizot, J; Darfeuille- Michaud, A; Barnich, N. High fat diet favours AIEC colonization and inflammation in CEABAC10 mice by modulating microflora composition. 8ème Rencontre des Microbiologistes du pôle Clermontois, Aubière (France). 2011.
Martinez-Medina, M; Garcia-Gil, M; Barnich, N; Wieler,L.H.; Ewers, C. Adherent-Invasive Escherichia coli (AIEC) – a group of pathogens associated with Crohn’s disease in humans – are frequently isolated from enteritis in cats, dogs, and swine. National Symposium on Zoonoses Research 2011, Berlin (GREMANY). 2011.
Martinez-Medina, M; Garcia-Gil, M; Barnich, N; Wieler,L.H.; Ewers, C. Animals as putative source of Adherent-Invasive Escherichia coli (AIEC) – a group of pathogens associated with Crohn’s disease in humans. 63rd Annual Meeting of the German Society for Hygiene and Microbiology (DGHM), Hamburg (GERMANY). 2011.
Martinez-Medina, M.; Aldeguer, X.; González-Huix, F.; Acero, D.; Blanco, J.; Garcia-Gil, L.J. Prevalence and diversity of AIEC in Crohn’s disease patients from Girona, Spain. 1st Workshop on Invasive E. coli and Crohn, Lille (France). Publicació: Journal of Crohn's and Colitis (2008) 2, 255–262. 2007. Invited talk
Martínez-Medina, M.; Aldeguer, X.; González-Huix, F.; Garcia-Gil, L.J. High prevalence of Escherichia coli in intestinal mucosa of Crohn’s disease patients compared with healthy controls. First Conference on New Frontiers on Microbiology and Infections. Lessons from Escherichia coli: from basic research to clinical aspects, Villars-sur-Ollon (Switzerland). 2005.
Martínez-Medina, M.; Aldeguer, X.; González-Huix, F.; Garcia-Gil, L.J. Anàlisi molecular dels bacteris íntimament associats a la mucosa intestinal de malalts de Crohn. XIV Congrés de la Societat Catalana de Digestologia, Roses (Spain). 2004.
Martínez-Medina, M.; Aldeguer, X.; González-Huix, F.; Garcia-Gil, L.J. Diversidad molecular de las bacterias íntimamente asociadas a la mucosa intestinal: en busca de marcadores microbianos de la enfermedad de Crohn. XIV Reunión nacional del GETECCU, Madrid (Spain). 2004.
Martínez-Medina M, Garcia-Gil, J. Diversitat de microbià de la colònia de Sant Jordi (Mallorca). Jornades sobre ambients aquàtics microestratificats, València (Spain). 2003.
Pòsters premiats
Martinez-Medina, M; Denizot, J; Darfeuille- Michaud, A; Barnich, N. 7th Congress of ECCO, Barcelona (SPAIN). 2012. 'Higlhy Commended”
Martinez-Medina, M; Denizot, J; Darfeuille- Michaud, A; Barnich, N. Westernalized diet on CEABAC10 mice induces a specific dysbiosis with increased Escherichia coli, modulates innate immune gene expression and favors AIEC colonization promoting inflammation. Digestive Disease Week 2012, San Diego (USA). 2012. ‘Top Poster’
Martinez-Medina, M; Denizot, J; Billard, E; Darfeuille- Michaud, A; Barnich, N. High fat diet modulates gut microbiota composition, favors AIEC colonization and promotes inflammation in CEABAC10 mice. 19th United European Digestive Week, Stockholm (SWEDEN). 2011. ‘Top Poster’.
Martinez-Medina, M.; Naves, P.; Blanco, J.; Aldeguer, X.; Blanco, JE.; Blanco, M.; Ponte, C.; Soriano, F.; and Garcia-Gil, LJ. Biofilm formation of Adherent-Invasive Escherichia coli (AIEC): a novel phenotypic trait that could be related to AIEC pathogenesis. 4th Congress of ECCO, Hamburg (GERMANY). Publicació: Journal of Crohn's and Colitis, 3(1):S136-S136. 2009. “Higlhy Commended”.
Lopez-Siles, M.; Martinez-Medina, M.; Aldeguer, X.; Garcia-Gil, LJ. Mucosa-associated Escherichia coli and Faecalibacterium prausnitzii quantification by real-time PCR and its potential use as complementary diagnostic tool for inflammatory bowel diseases. 4th Congress of ECCO, Hamburg (GERMANY). Publicació: Journal of Crohn's and Colitis, 3(1):S135-S135. 2009. “Poster of distinction”.
Beques i ajuts
Ajuts Complementaris per a la mobilitat d'Investigadors de la UdG 2005. Universitat de Girona.
Ajuts Complementaris per a la mobilitat d'Investigadors de la UdG 2006. Universitat de Girona.
Ajuts per a Estades Breus d’Internacionalització del PDI de la Universitat de Girona 2010. Universitat de Girona.
Travel Grant for the United European Gastroenterology Week ‘UEGW’ 2011. The United European Gastroenterology Federation (UEGF) and the World Gastroenterology Organisation (WGO)
Travel Grant for the INRA-Rowett conference 2012. FEMS Travel grants.
Ajuts per a la publicació d’articles vinculats a tesis doctorals (Convocatòria 2008). Universitat de Girona.
Travel Grant for the United European Gastroenterology Week ‘UEGW’ 2016. The United European Gastroenterology Federation (UEGF) and the World Gastroenterology Organisation (WGO)
Docència impartida
Màster
Patogenicitat Microbiana. Fonaments Moleculars, Màster Universitari en Biologia molecular i Biomedicina
Bioinforàtica, Màster Universitari en Biologia molecular i Biomedicina
Elements per a una diagnosi de la qualitat dels sistemes aquàtics continentals, Màster de l'Aigua
Graus
Microbiologia Clínica, Quart curs, Grau de Biologia
Microbiologia, Segon curs, Graus de Biologia i Biotecnologia
Pràctiques de Microbiologia, Segon curs, Grau de Biologia
Introducció a l'estudi de la Medicina. Interacció amb agressors de l'entorn 1, Segon Curs, Grau de Medicina
Fonaments de bioinformàtica, Tercer curs, Graus de Biologia i Biotecnologia
Llicenciatura
Anàlisis microbiològiques, Tercer curs, Biologia
Pràctiques de biologia fonamental, Segon curs, Ciències Ambientals
Virologia, BIOLOGIA, Segon curs, Biologia