1. Retrosynthetic analysis: 1.1 General principles of retrosynthetic analysis. 1.2 Disconnections. 1.3 Chemoselectivity and protecting groups. 1.4 Functional group interconversions. 1.5 Stereoselectivity and asymmetric synthesis
2. State-of-the-art strategies for transition metal-catalyzed bond forming processes:
2.1 Carbon-carbon bond-forming reactions
2.1.1 Functionalization of C-H substrates.
2.1.2 DirectingGroups: Ortho and meta C-H functionalization
2.1.3 TM-catalyzed Direct Arylation of Arenes with aryl-halides
2.1.4 TM-catalyzed Double arene C-H activation
2.1.5 Functionalization of C-F substrates.
2.2 Carbon-heteroatom bond-forming reactions.
2.2.1. C-N, C-O, C-S cross coupling reactions: Buchwald-Hartwig (Pd) and
Ullmann-type (Cu). Examples and Mechanisms.
2.2.2 C-H functionalization. Pd(II)/Pd(IV) redox cycles versus dinuclear-Pd(III)
for C-Heteroatom bond formation
2.2.4 Aryl, Alkenyl and Alkyl Fluorination (Pd, Ag, Au, Cu)
3. Solid-phase synthetic strategies:
3.1. General aspects
3.1.1. An overview on solid supports
3.1.3. Protecting groups
3.1.4. Reaction monitoring in solid-phase synthesis
3.2. Solid-phase synthesis of small organic compounds and biomolecules
3.3. Combinatorial synthesis
3.3.1. General aspects
3.3.2. Solid-phase library synthesis
3.3.3. Characterization and analysis of chemical libraries
All evaluation activities are to be done individually. The student must get a minimum mark of 4 for each of the evaluation activities in order for the activities to be considered in the final global evaluation mark.
Only the final examination can be repeated. In the case that a student repeats the final examination the new mark will substitute the old mark independently of whether this represents an improvement. Students wishing to repeat the final examination must notify the lecturer at least one week before the official date for resits
Criteris específics de la nota «No Presentat»:
A "Not presented" mark will only be considered if the student has not carried out any of the evaluation activities.