1. Protein engineering as a way to develop biological therapeutics.
Different examples of Knowledge-based mutagenesis (KBM) and directed evolution (DE) to develop or control the activity of protein drugs.
Screening methodologies of mutant libraries.
2. Modular drugs. Are the “magic bullets" possible? General survey and examples. Modular drugs and directed evolution as a way to control protein drug activity.
3. Targeted drug neutralization. Targeted rug activation: antibody-Drug conjugates (ADC), Engineered Zymogens (EZ), Directed Enzyme Prodrug therapy (DEPT), Light Responsive On/Off control of Drug Activity.
4. Examples of smart response drug system design. Engineering of protein Allostery. Stimulus-Responsive Drug release using biochemical logic (biomarkers and biosensors). Drug buffer.
Written reports and oral presentations will be individual whenever possible. If it is necessary to work in teams the final mark of the written report will be the same for all the team members unless negligence is detected.
In the oral presentation it is obligatory to specify which part of the work has done each team member independently of the organization of the exposition.
Criteris específics de la nota «No Presentat»:
The qualification will be NOT PRESENTED if the written report is not presented and/or the oral presentation is not given. It is mandatory the assistance to a minimum of the 80% of the sessions including the presentation of the rest of classmates.